DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jun Sung | ko |
dc.contributor.author | Lee, Hyoungjin | ko |
dc.contributor.author | Goh, Unbyeol | ko |
dc.contributor.author | Kim, Jiyoung | ko |
dc.contributor.author | Jeong, Moonkyoung | ko |
dc.contributor.author | Lee, Jean | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.date.accessioned | 2016-07-04T01:57:11Z | - |
dc.date.available | 2016-07-04T01:57:11Z | - |
dc.date.created | 2016-04-27 | - |
dc.date.created | 2016-04-27 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | ACS APPLIED MATERIALS & INTERFACES, v.8, no.11, pp.6790 - 6795 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/10203/208771 | - |
dc.description.abstract | Engineering of extracellular vesicles (EVs) without affecting biological functions remains a challenge, limiting the broad applications of EVs in biomedicine. Here, we report a method to equip EVs with various functional agents, including fluorophores, drugs, lipids, and bio-orthogonal chemicals, in an efficient and controlled manner by engineering parental cells with membrane fusogenic liposomes, while keeping the EVs intact. As a demonstration of how this method can be applied, we prepared EVs containing azide-lipids, and conjugated them with targeting peptides using copper-free click chemistry to enhance targeting efficacy to cancer cells. We believe that this liposome-based cellular engineering method will find utility in studying the biological roles of EVs and delivering therapeutic agents through their innate pathway | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | BREAST-CANCER CELLS | - |
dc.subject | EXOSOMES | - |
dc.subject | DELIVERY | - |
dc.subject | ELECTROPORATION | - |
dc.subject | STABILITY | - |
dc.subject | MECHANISM | - |
dc.subject | THERAPY | - |
dc.subject | BRAIN | - |
dc.subject | SIRNA | - |
dc.title | Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles | - |
dc.type | Article | - |
dc.identifier.wosid | 000372946600003 | - |
dc.identifier.scopusid | 2-s2.0-84962130194 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 6790 | - |
dc.citation.endingpage | 6795 | - |
dc.citation.publicationname | ACS APPLIED MATERIALS & INTERFACES | - |
dc.identifier.doi | 10.1021/acsami.6b01315 | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.nonIdAuthor | Lee, Hyoungjin | - |
dc.contributor.nonIdAuthor | Goh, Unbyeol | - |
dc.contributor.nonIdAuthor | Kim, Jiyoung | - |
dc.contributor.nonIdAuthor | Lee, Jean | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cellular engineering click chemistry | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | extracellular vesicle | - |
dc.subject.keywordAuthor | liposome | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ELECTROPORATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | SIRNA | - |
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