DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JH | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.contributor.author | Kim, TY | ko |
dc.contributor.author | Kim, Hyun Uk | ko |
dc.date.accessioned | 2010-12-08T09:25:49Z | - |
dc.date.available | 2010-12-08T09:25:49Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | TRENDS IN BIOTECHNOLOGY, v.26, no.8, pp.404 - 412 | - |
dc.identifier.issn | 0167-7799 | - |
dc.identifier.uri | http://hdl.handle.net/10203/20851 | - |
dc.description.abstract | Random mutagenesis or genetic modification of an organism without consideration of its consequences to the entire system might cause unwanted changes in cellular metabolism. Systems metabolic engineering thus aims to develop strains by performing metabolic engineering within a systems biology framework, in which entire cellular networks are optimized and fermentation and downstream processes are considered at early stages. Thus, regulatory, metabolic and other cellular networks are engineered in an integrated manner. Here, we review the applications of systems biology for the development of strains and bioprocesses by means of several successful examples and, furthermore, discuss future prospects. | - |
dc.description.sponsorship | This work was supported by a Genome-based Integrated Bioprocess Development grant from the Ministry of Education, Science and Technology through the Korea Science and Engineering Foundation. Further support from the LG Chem Chair Professorship and Microsoft is also appreciated. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE LONDON | - |
dc.title | Application of systems biology for bioprocess development | - |
dc.type | Article | - |
dc.identifier.wosid | 000258391100002 | - |
dc.identifier.scopusid | 2-s2.0-47249096975 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 404 | - |
dc.citation.endingpage | 412 | - |
dc.citation.publicationname | TRENDS IN BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1016/j.tibtech.2008.05.001 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.localauthor | Kim, Hyun Uk | - |
dc.contributor.nonIdAuthor | Park, JH | - |
dc.contributor.nonIdAuthor | Kim, TY | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | METABOLIC FLUX ANALYSIS | - |
dc.subject.keywordPlus | CAPNOPHILIC RUMEN BACTERIUM | - |
dc.subject.keywordPlus | GENOME-SCALE RECONSTRUCTION | - |
dc.subject.keywordPlus | GENE KNOCKOUT SIMULATION | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | MANNHEIMIA-SUCCINICIPRODUCENS | - |
dc.subject.keywordPlus | CORYNEBACTERIUM-GLUTAMICUM | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | SUCCINIC ACID | - |
dc.subject.keywordPlus | MODEL | - |
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