DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji Bak | ko |
dc.contributor.author | Park, Kyeongsoon | ko |
dc.contributor.author | Ryu, Jiheun | ko |
dc.contributor.author | Lee, Jae Joong | ko |
dc.contributor.author | Lee, Min Woo | ko |
dc.contributor.author | Cho, Han Saem | ko |
dc.contributor.author | Nam, Hyeong Soo | ko |
dc.contributor.author | Park, Ok Kyu | ko |
dc.contributor.author | Song, Joon Woo | ko |
dc.contributor.author | Kim, Tae Shik | ko |
dc.contributor.author | Oh, Dong Joo | ko |
dc.contributor.author | Gweon, DaeGab | ko |
dc.contributor.author | Oh, Wang-Yuhl | ko |
dc.contributor.author | Yoo, Hongki | ko |
dc.contributor.author | Kim, Jin Won | ko |
dc.date.accessioned | 2016-06-28T02:46:14Z | - |
dc.date.available | 2016-06-28T02:46:14Z | - |
dc.date.created | 2016-03-29 | - |
dc.date.created | 2016-03-29 | - |
dc.date.created | 2016-03-29 | - |
dc.date.created | 2016-03-29 | - |
dc.date.created | 2016-03-29 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.6 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/208164 | - |
dc.description.abstract | Macrophages mediate atheroma expansion and disruption, and denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone plaques. Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), and maleimide-polyethylene glycol-mannose as mannose receptor binding ligands to specifically target a subset of macrophages abundant in high-risk plaques. This probe showed high affinity to mannose receptors, low toxicity, and allowed the direct visualization of plaque macrophages in murine carotid atheroma. After the scale-up of the MMR-NIRF probe, the administration of the probe facilitated in vivo intravascular imaging of plaque inflammation in coronary-sized vessels of atheromatous rabbits using a custom-built dual-modal optical coherence tomography (OCT)-NIRF catheter-based imaging system. This novel imaging approach represents a potential imaging strategy enabling the identification of high-risk plaques in vivo and holds promise for future clinical implications. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors | - |
dc.type | Article | - |
dc.identifier.wosid | 000371406000001 | - |
dc.identifier.scopusid | 2-s2.0-84960364259 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep22608 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Gweon, DaeGab | - |
dc.contributor.localauthor | Oh, Wang-Yuhl | - |
dc.contributor.localauthor | Yoo, Hongki | - |
dc.contributor.nonIdAuthor | Kim, Ji Bak | - |
dc.contributor.nonIdAuthor | Park, Kyeongsoon | - |
dc.contributor.nonIdAuthor | Lee, Jae Joong | - |
dc.contributor.nonIdAuthor | Lee, Min Woo | - |
dc.contributor.nonIdAuthor | Nam, Hyeong Soo | - |
dc.contributor.nonIdAuthor | Park, Ok Kyu | - |
dc.contributor.nonIdAuthor | Song, Joon Woo | - |
dc.contributor.nonIdAuthor | Oh, Dong Joo | - |
dc.contributor.nonIdAuthor | Kim, Jin Won | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMAN ATHEROSCLEROTIC PLAQUES | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | CORONARY-DISEASE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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