DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tackhoon | ko |
dc.contributor.author | Yang, Suk-Jin | ko |
dc.contributor.author | Hwang, Daehee | ko |
dc.contributor.author | Song, Jinhoi | ko |
dc.contributor.author | Kim, Minchul | ko |
dc.contributor.author | Kim, Sang Kyum | ko |
dc.contributor.author | Kang, Keunsoo | ko |
dc.contributor.author | Ahn, Jaebum | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Kim, Mi-young | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.contributor.author | Koo, Ja Seung | ko |
dc.contributor.author | Koh, Sang Seok | ko |
dc.contributor.author | Kim, Seon-Young | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2016-06-07T09:11:56Z | - |
dc.date.available | 2016-06-07T09:11:56Z | - |
dc.date.created | 2016-01-25 | - |
dc.date.created | 2016-01-25 | - |
dc.date.created | 2016-01-25 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207807 | - |
dc.description.abstract | The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly understood. Here we show that the SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer. Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce numerous MaSC signature genes, among which the target interleukin (IL)-6 is critical for YAP-induced stemness. High SRF-YAP/TAZ expression is correlated with IL6-enriched MaSC/basal-like breast cancer (BLBC). Finally, we show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer. Collectively, our results establish the importance of SRF-YAP-IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness | - |
dc.type | Article | - |
dc.identifier.wosid | 000367575000002 | - |
dc.identifier.scopusid | 2-s2.0-84950273424 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms10186 | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Kim, Mi-young | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Yang, Suk-Jin | - |
dc.contributor.nonIdAuthor | Song, Jinhoi | - |
dc.contributor.nonIdAuthor | Kim, Sang Kyum | - |
dc.contributor.nonIdAuthor | Ahn, Jaebum | - |
dc.contributor.nonIdAuthor | Koo, Ja Seung | - |
dc.contributor.nonIdAuthor | Koh, Sang Seok | - |
dc.contributor.nonIdAuthor | Kim, Seon-Young | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COLITIS-ASSOCIATED CANCER | - |
dc.subject.keywordPlus | SERUM RESPONSE FACTOR | - |
dc.subject.keywordPlus | ONCOGENIC TRANSFORMATION | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | EXPRESSION SIGNATURE | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | ACTIN DYNAMICS | - |
dc.subject.keywordPlus | MAMMARY-GLAND | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | SRF ACTIVITY | - |
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