A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness

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dc.contributor.authorKim, Tackhoonko
dc.contributor.authorYang, Suk-Jinko
dc.contributor.authorHwang, Daeheeko
dc.contributor.authorSong, Jinhoiko
dc.contributor.authorKim, Minchulko
dc.contributor.authorKim, Sang Kyumko
dc.contributor.authorKang, Keunsooko
dc.contributor.authorAhn, Jaebumko
dc.contributor.authorLee, Daeyoupko
dc.contributor.authorKim, Mi-youngko
dc.contributor.authorKim, Seyunko
dc.contributor.authorKoo, Ja Seungko
dc.contributor.authorKoh, Sang Seokko
dc.contributor.authorKim, Seon-Youngko
dc.contributor.authorLim, Dae-Sikko
dc.date.accessioned2016-06-07T09:11:56Z-
dc.date.available2016-06-07T09:11:56Z-
dc.date.created2016-01-25-
dc.date.created2016-01-25-
dc.date.created2016-01-25-
dc.date.issued2015-12-
dc.identifier.citationNATURE COMMUNICATIONS, v.6-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/207807-
dc.description.abstractThe switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly understood. Here we show that the SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer. Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce numerous MaSC signature genes, among which the target interleukin (IL)-6 is critical for YAP-induced stemness. High SRF-YAP/TAZ expression is correlated with IL6-enriched MaSC/basal-like breast cancer (BLBC). Finally, we show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer. Collectively, our results establish the importance of SRF-YAP-IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleA basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness-
dc.typeArticle-
dc.identifier.wosid000367575000002-
dc.identifier.scopusid2-s2.0-84950273424-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/ncomms10186-
dc.contributor.localauthorLee, Daeyoup-
dc.contributor.localauthorKim, Mi-young-
dc.contributor.localauthorKim, Seyun-
dc.contributor.localauthorLim, Dae-Sik-
dc.contributor.nonIdAuthorYang, Suk-Jin-
dc.contributor.nonIdAuthorSong, Jinhoi-
dc.contributor.nonIdAuthorKim, Sang Kyum-
dc.contributor.nonIdAuthorAhn, Jaebum-
dc.contributor.nonIdAuthorKoo, Ja Seung-
dc.contributor.nonIdAuthorKoh, Sang Seok-
dc.contributor.nonIdAuthorKim, Seon-Young-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCOLITIS-ASSOCIATED CANCER-
dc.subject.keywordPlusSERUM RESPONSE FACTOR-
dc.subject.keywordPlusONCOGENIC TRANSFORMATION-
dc.subject.keywordPlusMESENCHYMAL TRANSITION-
dc.subject.keywordPlusEXPRESSION SIGNATURE-
dc.subject.keywordPlusCELL-PROLIFERATION-
dc.subject.keywordPlusACTIN DYNAMICS-
dc.subject.keywordPlusMAMMARY-GLAND-
dc.subject.keywordPlusHIPPO PATHWAY-
dc.subject.keywordPlusSRF ACTIVITY-
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