Regioselective enzymatic acylation of multi-hydroxyl compounds in organic synthesis

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With current developments in enzyme-catalyzed reactions and techniques available for rational redesign of natural biocatalysts, the enzymatic biosynthesis can become one of the most valuable synthetic methods. Enzymatic regioselective catalysis in organic media has played a key role in pursuing asymmetric synthesis for active chiral compounds. Here, we shortly describe some historical issues of the rapidly growing area, enzymatic catalysis in synthetic organic chemistry and then review researches that have been carried out in the regioselective enzymatic catalysis for the past two decades. An application of this technology to the modification of some potential target drug compound will be also presented.
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Issue Date
2003-01
Language
English
Article Type
Review
Keywords

SELECTIVE ACYLATION; NATURAL COMPOUNDS; DID BIOCATALYSIS; ESTERS; ENZYMES; SUGARS; MEDIA; DERIVATIVES; SOLVENTS; ESTERIFICATION

Citation

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.8, no.1, pp.1 - 8

ISSN
1226-8372
DOI
10.1007/BF02932891
URI
http://hdl.handle.net/10203/20780
Appears in Collection
CBE-Journal Papers(저널논문)
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