STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

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A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca2+ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca2+-alginate hydrogels. [GRAPHICS]
Publisher
WILEY-BLACKWELL
Issue Date
2016-03
Language
English
Article Type
Article
Keywords

CALCIUM-ALGINATE; BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; GROWTH-FACTOR; HYDROGELS; BEADS; MICROCAPSULES; CHITOSAN; RELEASE; ISLETS

Citation

ADVANCED HEALTHCARE MATERIALS, v.5, no.1, pp.75 - 79

ISSN
2192-2640
DOI
10.1002/adhm.201400833
URI
http://hdl.handle.net/10203/207708
Appears in Collection
CH-Journal Papers(저널논문)
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