DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Kyungeun | ko |
dc.contributor.author | Lee, Mi-Kyung | ko |
dc.contributor.author | Duong, Phuong Thi Mai | ko |
dc.contributor.author | Liu, Dinan | ko |
dc.contributor.author | Sung, Sieun | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.date.accessioned | 2016-05-16T08:57:33Z | - |
dc.date.available | 2016-05-16T08:57:33Z | - |
dc.date.created | 2015-12-10 | - |
dc.date.created | 2015-12-10 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | FEBS LETTERS, v.589, no.20, pp.3037 - 3043 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207534 | - |
dc.description.abstract | FAAP20 (Fanconi anemia-associated protein 20) is a subunit of the Fanconi anemia (FA) core complex that repairs interstrand cross-links. To understand the molecular basis for the FA core complex-mediated recruitment of Rev1 to the DNA lesion, we characterized the interactions among FAAP20-UBZ4, Rev1-BRCT, and ubiquidn using NMR. We found that FAAP20-UBZ4 binds not only ubiquitin but also Rev1-BRCT. Mapping the protein-protein interactions showed that FAAP20-UBZ4 has distinct binding surfaces for ubiquitin and Rev1-BRCT. In addition, the chemical exchange patterns indicated that the interaction between FAAP20-UBZ4 and ubiquitin might enhance the binding affinity between FAAP20-UBZ4 and Rev1-BRCT. These results provide new insight into the Rev1 recognition mechanism by FAAP20. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CROSS-LINK REPAIR | - |
dc.subject | FANCONI-ANEMIA | - |
dc.subject | DNA-REPAIR | - |
dc.subject | BINDING-PROTEIN | - |
dc.subject | CORE-COMPLEX | - |
dc.subject | POLYMERASES | - |
dc.subject | PATHWAY | - |
dc.title | Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain | - |
dc.type | Article | - |
dc.identifier.wosid | 000364604800001 | - |
dc.identifier.scopusid | 2-s2.0-84943200901 | - |
dc.type.rims | ART | - |
dc.citation.volume | 589 | - |
dc.citation.issue | 20 | - |
dc.citation.beginningpage | 3037 | - |
dc.citation.endingpage | 3043 | - |
dc.citation.publicationname | FEBS LETTERS | - |
dc.identifier.doi | 10.1016/j.febslet.2015.08.021 | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | Lee, Mi-Kyung | - |
dc.contributor.nonIdAuthor | Liu, Dinan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Fanconi anemia pathway | - |
dc.subject.keywordAuthor | Interstrand cross-link | - |
dc.subject.keywordAuthor | Fanconi anemia-associated protein 20 | - |
dc.subject.keywordAuthor | Rev1 | - |
dc.subject.keywordAuthor | Ubiquitin | - |
dc.subject.keywordAuthor | Nuclear magnetic resonance | - |
dc.subject.keywordPlus | CROSS-LINK REPAIR | - |
dc.subject.keywordPlus | FANCONI-ANEMIA | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | CORE-COMPLEX | - |
dc.subject.keywordPlus | POLYMERASES | - |
dc.subject.keywordPlus | PATHWAY | - |
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