DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2016-05-16T08:44:42Z | - |
dc.date.available | 2016-05-16T08:44:42Z | - |
dc.date.created | 2016-02-22 | - |
dc.date.created | 2016-02-22 | - |
dc.date.created | 2016-02-22 | - |
dc.date.created | 2016-02-22 | - |
dc.date.created | 2016-02-22 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.196 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207425 | - |
dc.description.abstract | Commensal microbiota are well known to play an important role in antiviral immunity by providing immune inductive signals; however, the consequence of dysbiosis on antiviral immunity remains unclear. We demonstrate that dysbiosis caused by oral antibiotic treatment directly impairs antiviral immunity following viral infection of the vaginalmucosa. Antibiotic-treatedmice succumbed to mucosal herpes simplex virus type 2 infection more rapidly than water-fed mice, and also showed delayed viral clearance at the site of infection. However, innate immune responses, including type I IFN and proinflammatory cytokine production at infection sites, as well as induction of virus-specific CD4 and CD8 T-cell responses in draining lymph nodes, were not impaired in antibiotic-treated mice. By screening the factors controlling antiviral immunity, we found that IL-33, an alarmin released in response to tissue damage, was secreted from vaginal epithelium after the depletion of commensal microbiota. This cytokine suppresses local antiviral immunity by blocking the migration of effector T cells to the vaginal tissue, thereby inhibiting the production of IFN-gamma, a critical cytokine for antiviral defense, at local infection sites. These findings provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa | - |
dc.type | Article | - |
dc.identifier.wosid | 000369571700013 | - |
dc.identifier.scopusid | 2-s2.0-84957831444 | - |
dc.type.rims | ART | - |
dc.citation.volume | 196 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1518589113 | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | commensal microbiota | - |
dc.subject.keywordAuthor | dysbiosis | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordAuthor | herpes simplex virus type 2 | - |
dc.subject.keywordAuthor | genital tract | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | HERPES-SIMPLEX-VIRUS | - |
dc.subject.keywordPlus | SERRATIA-MARCESCENS | - |
dc.subject.keywordPlus | COMMENSAL MICROBIOTA | - |
dc.subject.keywordPlus | BACTERIAL VAGINOSIS | - |
dc.subject.keywordPlus | ADAPTIVE IMMUNITY | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
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