Global physiological understanding and metabolic engineering of microorganisms based on omics studies

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Through metabolic engineering, scientists seek to modify the metabolic pathways of living organisms to facilitate optimized, efficient production of target biomolecules. During the past decade, we have seen notable improvements in biotechnology, many of which have been based on metabolically engineered microorganisms. Recent developments in the fields of functional genomics, transcriptomics, proteomics, and metabolomics have changed metabolic engineering strategies from the local pathway level to the whole system level. This article focuses on recent advances in the field of metabolic engineering, which have been powered by the combined approaches of the various "omics" that allow us to understand the microbial metabolism at a global scale and to develop more effectively redesigned metabolic pathways for the enhanced production of target bioproducts.
Publisher
SPRINGER
Issue Date
2005-09
Language
English
Article Type
Review
Keywords

ESCHERICHIA-COLI K-12; QUANTITATIVE PROTEOMIC ANALYSIS; PROTEIN EXPRESSION PATTERNS; MESSENGER-RNA ABUNDANCE; DNA MICROARRAY ANALYSIS; CELL-DENSITY CULTURE; CODED AFFINITY TAGS; BACILLUS-SUBTILIS; GENE-EXPRESSION; MASS-SPECTROMETRY

Citation

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.68, pp.567 - 579

ISSN
0175-7598
DOI
10.1007/s00253-005-0081-z
URI
http://hdl.handle.net/10203/20735
Appears in Collection
CBE-Journal Papers(저널논문)
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