DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung Eun | ko |
dc.contributor.author | Park, Hansoo | ko |
dc.contributor.author | Ju, Young Seok | ko |
dc.contributor.author | Kwak, Minhye | ko |
dc.contributor.author | Kim, Jong-Il | ko |
dc.contributor.author | Oh, Ha Young | ko |
dc.contributor.author | Seo, Jeong-Sun | ko |
dc.date.accessioned | 2016-05-10T08:28:12Z | - |
dc.date.available | 2016-05-10T08:28:12Z | - |
dc.date.created | 2015-12-09 | - |
dc.date.created | 2015-12-09 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.41, no.4, pp.253 - 258 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207110 | - |
dc.description.abstract | It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondriall DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | SUPEROXIDE-PRODUCTION | - |
dc.subject | DYSFUNCTION | - |
dc.subject | DAMAGE | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | ATHEROGENESIS | - |
dc.subject | HYPOTHESIS | - |
dc.subject | PATHWAYS | - |
dc.subject | MUSCLE | - |
dc.subject | CELLS | - |
dc.title | Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria | - |
dc.type | Article | - |
dc.identifier.wosid | 000265842900005 | - |
dc.identifier.scopusid | 2-s2.0-65949090721 | - |
dc.type.rims | ART | - |
dc.citation.volume | 41 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 253 | - |
dc.citation.endingpage | 258 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.3858/emm.2009.41.4.028 | - |
dc.contributor.localauthor | Ju, Young Seok | - |
dc.contributor.nonIdAuthor | Lee, Jung Eun | - |
dc.contributor.nonIdAuthor | Park, Hansoo | - |
dc.contributor.nonIdAuthor | Kwak, Minhye | - |
dc.contributor.nonIdAuthor | Kim, Jong-Il | - |
dc.contributor.nonIdAuthor | Oh, Ha Young | - |
dc.contributor.nonIdAuthor | Seo, Jeong-Sun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | albuminuria | - |
dc.subject.keywordAuthor | cardiovascular diseases | - |
dc.subject.keywordAuthor | DNA, mitochondrial | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | oxidative phosphorylation | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | SUPEROXIDE-PRODUCTION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | ATHEROGENESIS | - |
dc.subject.keywordPlus | HYPOTHESIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | CELLS | - |
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