DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jong Il | ko |
dc.contributor.author | Ju, Young Seok | ko |
dc.contributor.author | Park, Han Soo | ko |
dc.contributor.author | Kim, Shee Hyun | ko |
dc.contributor.author | Lee, Seon Wook | ko |
dc.contributor.author | Yi, Jae Hyuk | ko |
dc.contributor.author | Mudge, Joann | ko |
dc.contributor.author | Miller, Neil A | ko |
dc.contributor.author | Hong, Dong Wan | ko |
dc.contributor.author | Bell, Callum J | ko |
dc.contributor.author | Kim, Hye Sun | ko |
dc.contributor.author | Chung, In Soon | ko |
dc.contributor.author | Lee, Woo Chung | ko |
dc.contributor.author | Lee, Ji Sun | ko |
dc.contributor.author | Seo, Seung Hyun | ko |
dc.contributor.author | Yun, Ji Young | ko |
dc.contributor.author | Woo, Hyun Nyun | ko |
dc.contributor.author | Lee, Hee Wook | ko |
dc.contributor.author | Suh, Dong Whan | ko |
dc.contributor.author | Lee, Seung Bok | ko |
dc.contributor.author | Kim, Hyun Jin | ko |
dc.contributor.author | Yavartanoo, Maryam | ko |
dc.contributor.author | Kwak, Min Hye | ko |
dc.contributor.author | Zheng, Ying | ko |
dc.contributor.author | Lee, Mi Kyeong | ko |
dc.contributor.author | Park, Hyun Jun | ko |
dc.contributor.author | Kim, Jeong Yeon | ko |
dc.contributor.author | Gokcumen, Omer | ko |
dc.contributor.author | Mills, Ryan E | ko |
dc.contributor.author | Zaranek, Alexander Wait | ko |
dc.contributor.author | Thakuria, Joseph | ko |
dc.contributor.author | Wu, Xiaodi | ko |
dc.contributor.author | Kim, Ryan W | ko |
dc.contributor.author | Huntley, Jim J | ko |
dc.contributor.author | Luo, Shu Jun | ko |
dc.contributor.author | Schroth, Gary P | ko |
dc.contributor.author | Wu, Thomas D | ko |
dc.contributor.author | Kim, Hye Ran | ko |
dc.contributor.author | Yang, Kap Seok | ko |
dc.contributor.author | Park, Woong Yang | ko |
dc.contributor.author | Kim, Hyung Tae | ko |
dc.contributor.author | Church, George M | ko |
dc.contributor.author | Lee, Charles | ko |
dc.contributor.author | Kingsmore, Stephen F | ko |
dc.contributor.author | Seo, Jeong Sun | ko |
dc.date.accessioned | 2016-05-10T08:27:40Z | - |
dc.date.available | 2016-05-10T08:27:40Z | - |
dc.date.created | 2015-12-09 | - |
dc.date.created | 2015-12-09 | - |
dc.date.created | 2015-12-09 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | NATURE, v.460, no.7258, pp.1011 - U96 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/207107 | - |
dc.description.abstract | Recent advances in sequencing technologies have initiated an era of personal genome sequences. To date, human genome sequences have been reported for individuals with ancestry in three distinct geographical regions: a Yoruba African, two individuals of northwest European origin, and a person from China(1-4). Here we provide a highly annotated, whole-genome sequence for a Korean individual, known as AK1. The genome of AK1 was determined by an exacting, combined approach that included whole-genome shot-gun sequencing (27.8x coverage), targeted bacterial artificial chromosome sequencing, and high-resolution comparative genomic hybridization using custom microarrays featuring more than 24 million probes. Alignment to the NCBI reference, a composite of several ethnic clades(5,6), disclosed nearly 3.45 million single nucleotide polymorphisms ( SNPs), including 10,162 non-synonymous SNPs, and 170,202 deletion or insertion polymorphisms (indels). SNP and indel densities were strongly correlated genome-wide. Applying very conservative criteria yielded highly reliable copy number variants for clinical considerations. Potential medical phenotypes were annotated for non-synonymous SNPs, coding domain indels, and structural variants. The integration of several human whole-genome sequences derived from several ethnic groups will assist in understanding genetic ancestry, migration patterns and population bottlenecks. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | A highly annotated whole-genome sequence of a Korean individual | - |
dc.type | Article | - |
dc.identifier.wosid | 000269085500034 | - |
dc.identifier.scopusid | 2-s2.0-69249232047 | - |
dc.type.rims | ART | - |
dc.citation.volume | 460 | - |
dc.citation.issue | 7258 | - |
dc.citation.beginningpage | 1011 | - |
dc.citation.endingpage | U96 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature08211 | - |
dc.contributor.localauthor | Ju, Young Seok | - |
dc.contributor.nonIdAuthor | Kim, Jong Il | - |
dc.contributor.nonIdAuthor | Park, Han Soo | - |
dc.contributor.nonIdAuthor | Kim, Shee Hyun | - |
dc.contributor.nonIdAuthor | Lee, Seon Wook | - |
dc.contributor.nonIdAuthor | Yi, Jae Hyuk | - |
dc.contributor.nonIdAuthor | Mudge, Joann | - |
dc.contributor.nonIdAuthor | Miller, Neil A | - |
dc.contributor.nonIdAuthor | Hong, Dong Wan | - |
dc.contributor.nonIdAuthor | Bell, Callum J | - |
dc.contributor.nonIdAuthor | Kim, Hye Sun | - |
dc.contributor.nonIdAuthor | Chung, In Soon | - |
dc.contributor.nonIdAuthor | Lee, Woo Chung | - |
dc.contributor.nonIdAuthor | Lee, Ji Sun | - |
dc.contributor.nonIdAuthor | Seo, Seung Hyun | - |
dc.contributor.nonIdAuthor | Yun, Ji Young | - |
dc.contributor.nonIdAuthor | Woo, Hyun Nyun | - |
dc.contributor.nonIdAuthor | Lee, Hee Wook | - |
dc.contributor.nonIdAuthor | Suh, Dong Whan | - |
dc.contributor.nonIdAuthor | Lee, Seung Bok | - |
dc.contributor.nonIdAuthor | Kim, Hyun Jin | - |
dc.contributor.nonIdAuthor | Yavartanoo, Maryam | - |
dc.contributor.nonIdAuthor | Kwak, Min Hye | - |
dc.contributor.nonIdAuthor | Zheng, Ying | - |
dc.contributor.nonIdAuthor | Lee, Mi Kyeong | - |
dc.contributor.nonIdAuthor | Park, Hyun Jun | - |
dc.contributor.nonIdAuthor | Kim, Jeong Yeon | - |
dc.contributor.nonIdAuthor | Gokcumen, Omer | - |
dc.contributor.nonIdAuthor | Mills, Ryan E | - |
dc.contributor.nonIdAuthor | Zaranek, Alexander Wait | - |
dc.contributor.nonIdAuthor | Thakuria, Joseph | - |
dc.contributor.nonIdAuthor | Wu, Xiaodi | - |
dc.contributor.nonIdAuthor | Kim, Ryan W | - |
dc.contributor.nonIdAuthor | Huntley, Jim J | - |
dc.contributor.nonIdAuthor | Luo, Shu Jun | - |
dc.contributor.nonIdAuthor | Schroth, Gary P | - |
dc.contributor.nonIdAuthor | Wu, Thomas D | - |
dc.contributor.nonIdAuthor | Kim, Hye Ran | - |
dc.contributor.nonIdAuthor | Yang, Kap Seok | - |
dc.contributor.nonIdAuthor | Park, Woong Yang | - |
dc.contributor.nonIdAuthor | Kim, Hyung Tae | - |
dc.contributor.nonIdAuthor | Church, George M | - |
dc.contributor.nonIdAuthor | Lee, Charles | - |
dc.contributor.nonIdAuthor | Kingsmore, Stephen F | - |
dc.contributor.nonIdAuthor | Seo, Jeong Sun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | EVOLUTION | - |
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