Regulatory analysis of amino acid synthesis pathway in Escherichia coli: aspartate family

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Proteins have various compositions of twenty specific naturally occurring amino acids. In spite of their importance in cellular metabolism, biosynthesis mechanisms, changing control conditions, and affection of effectors are not clearly understood yet. So we have made an effort to elucidate the details of metabolic control mechanisms in amino acid synthesis pathways through examining an extensive database search. In this study, we have newly constructed six amino acid biosynthesis pathways including aspartate, asparagine, methionine, threonine, isoleucine, and lysine, which we call the aspartate family. They contain the major reaction mechanisms, which inhibitory control loops and activating compounds. Moreover, we have tried to collect all of the effectors which might affect the aspartate family biosynthetic networks. (C) 2004 Elsevier Inc. All rights reserved.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2004-12
Language
English
Article Type
Article; Proceedings Paper
Citation

ENZYME AND MICROBIAL TECHNOLOGY, v.35, pp.694 - 706

ISSN
0141-0229
URI
http://hdl.handle.net/10203/20664
Appears in Collection
CBE-Journal Papers(저널논문)
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