Engineering Escherichia coli to overproduce cadaverine

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Cadaverine (1,5-diaminopentane) is a five-carbon diamine that can be used forsustainable polymer production. Microbial production of cadaverine from renewablefeedstock is a promising and sustainable alternative to the conventional petroleumbasedchemical synthesis. Herein, we report a metabolically engineered Escherichia colistrain capable of overproducing cadaverine from glucose in minimal salts medium. Withthe pathways that lead to cadaverine degradation deleted, the final engineered strainproduced 9.61 g/L of cadaverine with a productivity of 0.32 g/L/h by fed-batchfermentation. [This work was supported by the Technology Development Program toSolve Climate Changes on Systems Metabolic Engineering for Biorefineries from theMinistry of Science, ICT and Future Planning (MSIP) through the National ResearchFoundation (NRF) of Korea.]
Publisher
한국화학공학회
Issue Date
2015-10-23
Language
English
Citation

2015 KIChE Fall Meeting, pp.1737 - 1737

ISSN
1225-9004
URI
http://hdl.handle.net/10203/205809
Appears in Collection
CBE-Conference Papers(학술회의논문)
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