DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Yan | ko |
dc.contributor.author | Zhang, Peng | ko |
dc.contributor.author | Choi, Tae-Yong | ko |
dc.contributor.author | Park, Sook Kyung | ko |
dc.contributor.author | Park, Hanwool | ko |
dc.contributor.author | Lee, Eun-Jae | ko |
dc.contributor.author | Lee, Dongsoo | ko |
dc.contributor.author | Roh, Junyeop Daniel | ko |
dc.contributor.author | Mah, Won | ko |
dc.contributor.author | Kim, Ryunhee | ko |
dc.contributor.author | Kim, Y | ko |
dc.contributor.author | Kwon, Harah | ko |
dc.contributor.author | Bae, Yong Chul | ko |
dc.contributor.author | Choi, Se-Young | ko |
dc.contributor.author | Craig, Ann Marie | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2016-04-20T06:58:18Z | - |
dc.date.available | 2016-04-20T06:58:18Z | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | CELL REPORTS, v.12, no.10, pp.1618 - 1630 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205607 | - |
dc.description.abstract | Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. SALM3 mutant (Salm3(-/-)) mice display markedly reduced excitatory synapse number but normal synaptic plasticity in the hippocampal CA1 region. Salm3(-/-) mice exhibit hypoactivity in both novel and familiar environments but perform normally in learning and memory tests administered. These results suggest that SALM3 regulates excitatory synapse development and locomotion behavior. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion | - |
dc.type | Article | - |
dc.identifier.wosid | 000360965500011 | - |
dc.identifier.scopusid | 2-s2.0-84941177364 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 1618 | - |
dc.citation.endingpage | 1630 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2015.08.002 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Zhang, Peng | - |
dc.contributor.nonIdAuthor | Choi, Tae-Yong | - |
dc.contributor.nonIdAuthor | Park, Sook Kyung | - |
dc.contributor.nonIdAuthor | Lee, Dongsoo | - |
dc.contributor.nonIdAuthor | Roh, Junyeop Daniel | - |
dc.contributor.nonIdAuthor | Mah, Won | - |
dc.contributor.nonIdAuthor | Kwon, Harah | - |
dc.contributor.nonIdAuthor | Bae, Yong Chul | - |
dc.contributor.nonIdAuthor | Choi, Se-Young | - |
dc.contributor.nonIdAuthor | Craig, Ann Marie | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE PHOSPHATASES | - |
dc.subject.keywordPlus | AUTISM SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | ADHESION-LIKE MOLECULES | - |
dc.subject.keywordPlus | RICH REPEAT PROTEINS | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | INTELLECTUAL DISABILITY | - |
dc.subject.keywordPlus | TRANSMEMBRANE PROTEINS | - |
dc.subject.keywordPlus | MENTAL-RETARDATION | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordPlus | RECEPTOR | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.