DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hanwool | ko |
dc.contributor.author | Yang, Jin-Hee | ko |
dc.contributor.author | Kim, Ryunhee | ko |
dc.contributor.author | Li, Yan | ko |
dc.contributor.author | Lee, Yeunkum | ko |
dc.contributor.author | Lee, Chungwoo | ko |
dc.contributor.author | Park, Jongil | ko |
dc.contributor.author | Lee, Dongmin | ko |
dc.contributor.author | Kim, Hyun | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2016-04-20T06:52:42Z | - |
dc.date.available | 2016-04-20T06:52:42Z | - |
dc.date.created | 2015-12-01 | - |
dc.date.created | 2015-12-01 | - |
dc.date.created | 2015-12-01 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.5 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205547 | - |
dc.description.abstract | Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson's disease, but its in vivo functions have not been explored. We report here that Dorfin is a novel binding partner of the excitatory postsynaptic scaffolding protein PSD95. Dorfin-mutant (Dorfin(-/-)) mice show reduced adult neurogenesis and enhanced long-term potentiation in the hippocampal dentate gyrus, but normal long-term potentiation in the CA1 region. Behaviorally, Dorfin(-/-) mice show impaired contextual fear conditioning, but normal levels of cued fear conditioning, fear extinction, spatial learning and memory, object recognition memory, spatial working memory, and pattern separation. Using a proteomic approach, we also identify a number of proteins whose ubiquitination levels are decreased in the Dorfin(-/-) brain. These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning | - |
dc.type | Article | - |
dc.identifier.wosid | 000364385500002 | - |
dc.identifier.scopusid | 2-s2.0-84946950124 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep16410 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Li, Yan | - |
dc.contributor.nonIdAuthor | Lee, Yeunkum | - |
dc.contributor.nonIdAuthor | Lee, Chungwoo | - |
dc.contributor.nonIdAuthor | Park, Jongil | - |
dc.contributor.nonIdAuthor | Lee, Dongmin | - |
dc.contributor.nonIdAuthor | Kim, Hyun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | ACTIVITY-DEPENDENT UBIQUITINATION | - |
dc.subject.keywordPlus | HIPPOCAMPAL SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | ANAPHASE-PROMOTING COMPLEX | - |
dc.subject.keywordPlus | RING-FINGER PROTEIN | - |
dc.subject.keywordPlus | AMPA RECEPTORS | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | PATTERN SEPARATION | - |
dc.subject.keywordPlus | MUTANT SOD1 | - |
dc.subject.keywordPlus | UBIQUITYLATED INCLUSIONS | - |
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