A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributed Pseudomonas aeruginosa clone C strains

Cited 14 time in webofscience Cited 0 time in scopus
  • Hit : 252
  • Download : 0
Pseudomonas aeruginosa is a highly successful nosocomial pathogen capable of causing a wide variety of infectionswithclone C strains most prevalentworldwide. In this study, we initially characterize a molecular mechanism of survival unique to clone C strains. We identified aP.aeruginosa clone C-specific genomic island (PACGI-1) that contains the highly expressed small heat shock protein sHsp20c, the founding member of a novel subclass of class B bacterial small heat shock proteins. sHsp20c and adjacent gene products are involved in resistance against heat shock.Heat stable sHsp20c is unconventionally expressed in stationary phase in a wide temperature range from 20 to 42 degrees C. PurifiedsHsp20c has characteristic features of small heat shock protein class B as it is monodisperse, forms sphere-like 24-meric oligomers and exhibits significant chaperone activity. As theP.aeruginosaclone C population is significantly more heat shock resistant than genetically unrelated P.aeruginosa strains without sHsp20c, the horizontally acquired shsp20c operon might contribute to the survival of worldwide-distributed clone C strains.
Publisher
WILEY-BLACKWELL
Issue Date
2015-11
Language
English
Article Type
Article
Keywords

ESCHERICHIA-COLI; CYSTIC-FIBROSIS; MOLECULAR CHAPERONE; SEDIMENTATION EQUILIBRIUM; GENOMIC ISLANDS; EVOLUTION; EXPRESSION; ENVIRONMENT; INFECTIONS; GENES

Citation

ENVIRONMENTAL MICROBIOLOGY, v.17, no.11, pp.4511 - 4526

ISSN
1462-2912
DOI
10.1111/1462-2920.12915
URI
http://hdl.handle.net/10203/205535
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 14 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0