DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Youngsam | ko |
dc.contributor.author | Mulay, Sandip V. | ko |
dc.contributor.author | Choi, Minsuk | ko |
dc.contributor.author | Yu, Seungyoon B. | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Churchill, David G | ko |
dc.date.accessioned | 2016-04-20T06:35:47Z | - |
dc.date.available | 2016-04-20T06:35:47Z | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | CHEMICAL SCIENCE, v.6, no.10, pp.5435 - 5439 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://hdl.handle.net/10203/205456 | - |
dc.description.abstract | A phenyl-selenium-substituted coumarin probe was synthesized for the purpose of achieving highly selective and extremely rapid detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy) without background fluorescence. The fluorescence intensity of the probe with GSH shows a similar to 100-fold fluorescent enhancement compared with the signal generated for other closely related amino acids, including Cys and Hcy. Importantly, the substitution reaction with the sulfhydryl group of GSH at the 4-position of the probe, which is doubly-activated by two carbonyl groups, occurs extremely fast, showing subsecond maximum fluorescence intensity attainment; equilibrium was reached within 100 ms (UV-vis). The probe selectivity for GSH was confirmed in Hep3B cells by confocal microscopy imaging. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Exceptional time response, stability and selectivity in doubly-activated phenyl selenium-based glutathione-selective platform | - |
dc.type | Article | - |
dc.identifier.wosid | 000361212000010 | - |
dc.identifier.scopusid | 2-s2.0-84941636053 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 5435 | - |
dc.citation.endingpage | 5439 | - |
dc.citation.publicationname | CHEMICAL SCIENCE | - |
dc.identifier.doi | 10.1039/c5sc02090e | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Churchill, David G | - |
dc.contributor.nonIdAuthor | Mulay, Sandip V. | - |
dc.contributor.nonIdAuthor | Choi, Minsuk | - |
dc.contributor.nonIdAuthor | Yu, Seungyoon B. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DIFFERENT EMISSION CHANNELS | - |
dc.subject.keywordPlus | FLUORESCENT-PROBE | - |
dc.subject.keywordPlus | DESIGN STRATEGIES | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | CYSTEINE | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | THIOLS | - |
dc.subject.keywordPlus | GSH | - |
dc.subject.keywordPlus | CHEMOSENSORS | - |
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