Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy

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dc.contributor.authorSharker, Shazid Md.ko
dc.contributor.authorKim, Sung Minko
dc.contributor.authorLee, Jung Eunko
dc.contributor.authorChoi, Kyung Hoko
dc.contributor.authorShin, Gyojicko
dc.contributor.authorLee, Sangkugko
dc.contributor.authorLee, Kang Daeko
dc.contributor.authorJeong, Ji Hoonko
dc.contributor.authorLee, Haeshinko
dc.contributor.authorPark, Sung Youngko
dc.date.accessioned2016-04-20T06:13:27Z-
dc.date.available2016-04-20T06:13:27Z-
dc.date.created2015-11-30-
dc.date.created2015-11-30-
dc.date.issued2015-11-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v.217, pp.211 - 220-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10203/205180-
dc.description.abstractWe report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of similar to 10 nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectHYALURONIC-ACID NANOPARTICLES-
dc.subjectREDUCED GRAPHENE OXIDE-
dc.subject980 NM-LASER-
dc.subjectCARBON NANOPARTICLES-
dc.subjectGOLD NANOPARTICLES-
dc.subjectPOLYMER-
dc.subjectLIGHT-
dc.subjectCHEMISTRY-
dc.subjectABLATION-
dc.subjectDELIVERY-
dc.titleFunctionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy-
dc.typeArticle-
dc.identifier.wosid000363481500021-
dc.identifier.scopusid2-s2.0-84941955974-
dc.type.rimsART-
dc.citation.volume217-
dc.citation.beginningpage211-
dc.citation.endingpage220-
dc.citation.publicationnameJOURNAL OF CONTROLLED RELEASE-
dc.identifier.doi10.1016/j.jconrel.2015.09.010-
dc.contributor.localauthorLee, Haeshin-
dc.contributor.nonIdAuthorKim, Sung Min-
dc.contributor.nonIdAuthorLee, Jung Eun-
dc.contributor.nonIdAuthorChoi, Kyung Ho-
dc.contributor.nonIdAuthorShin, Gyojic-
dc.contributor.nonIdAuthorLee, Sangkug-
dc.contributor.nonIdAuthorLee, Kang Dae-
dc.contributor.nonIdAuthorJeong, Ji Hoon-
dc.contributor.nonIdAuthorPark, Sung Young-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorWO3-
dc.subject.keywordAuthorHyaluronic acid-
dc.subject.keywordAuthorBiocompatibility-
dc.subject.keywordAuthorTarget delivery-
dc.subject.keywordAuthorPhotothermal therapy-
dc.subject.keywordPlusHYALURONIC-ACID NANOPARTICLES-
dc.subject.keywordPlusREDUCED GRAPHENE OXIDE-
dc.subject.keywordPlus980 NM-LASER-
dc.subject.keywordPlusCARBON NANOPARTICLES-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusPOLYMER-
dc.subject.keywordPlusLIGHT-
dc.subject.keywordPlusCHEMISTRY-
dc.subject.keywordPlusABLATION-
dc.subject.keywordPlusDELIVERY-
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