Depletion of fat-resident T-reg cells prevents age-associated insulin resistance

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Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR1-6, the underlying mechanisms of the obesity-independent yet highly prevalent age-associated IR7 are largely unexplored. Here we show, using comparative adipo-immune profiling in mice, that fat-resident regulatory T cells, termed fT(reg) cells, accumulate in adipose tissue as a function of age, but not obesity. Supporting the existence of two distinct mechanisms underlying IR, mice deficient in fT(reg) cells are protected against age-associated IR, yet remain susceptible to obesity-associated IR and metabolic disease. By contrast, selective depletion of fT(reg) cells via anti-ST2 antibody treatment increases adipose tissue insulin sensitivity. These findings establish that distinct immune cell populations within adipose tissue underlie ageing- and obesity-associated IR, and implicate fT(reg) cells as adipo-immune drivers and potential therapeutic targets in the treatment of age-associated IR.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2015-12
Language
English
Article Type
Article
Keywords

VISCERAL ADIPOSE-TISSUE; RNA-SEQ; ORCHESTRATE DEVELOPMENT; PPAR-GAMMA; BEIGE FAT; MACROPHAGES; OBESITY; INFLAMMATION; DIFFERENTIATION; ACCUMULATION

Citation

NATURE, v.528, no.7580, pp.137 - 137

ISSN
0028-0836
DOI
10.1038/nature16151
URI
http://hdl.handle.net/10203/205130
Appears in Collection
MSE-Journal Papers(저널논문)
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