DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Je-Hyun | ko |
dc.contributor.author | Jo, Myung Hyun | ko |
dc.contributor.author | White, Elizabeth J. F. | ko |
dc.contributor.author | De, Supriyo | ko |
dc.contributor.author | Hafner, Markus | ko |
dc.contributor.author | Zucconi, Beth E. | ko |
dc.contributor.author | Abdelmohsen, Kotb | ko |
dc.contributor.author | Martindale, Jennifer L. | ko |
dc.contributor.author | Yang, Xiaoling | ko |
dc.contributor.author | Wood, William H., III | ko |
dc.contributor.author | Shin, Yu Mi | ko |
dc.contributor.author | Song, Ji-Joon | ko |
dc.contributor.author | Tuschl, Thomas | ko |
dc.contributor.author | Becker, Kevin G. | ko |
dc.contributor.author | Wilson, Gerald M. | ko |
dc.contributor.author | Hohng, Sungchul | ko |
dc.contributor.author | Gorospe, Myriam | ko |
dc.date.accessioned | 2016-04-15T03:06:49Z | - |
dc.date.available | 2016-04-15T03:06:49Z | - |
dc.date.created | 2015-09-07 | - |
dc.date.created | 2015-09-07 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | GENES & DEVELOPMENT, v.29, no.15, pp.1599 - 1604 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10203/203972 | - |
dc.description.abstract | Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins (RBPs) and microRNAs. The RBP AU-rich-binding factor 1 (AUF1) isoform p37 was found to have high affinity for the microRNA let-7b in vitro (K-d = similar to 6 nM) in cells. Ribonucleoprotein immunoprecipitation, in vitro association, and single-molecule-binding analyses revealed that AUF1 promoted let-7b loading onto Argonaute 2 (AGO2), the catalytic component of the RNA-induced silencing complex (RISC). In turn, AGO2-let-7 triggered target mRNA decay. Our findings uncover a novel mechanism by which AUF1 binding and transfer of microRNA let-7 to AGO2 facilitates let-7-elicited gene silencing. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | - |
dc.title | AUF1 promotes let-7b loading on Argonaute 2 | - |
dc.type | Article | - |
dc.identifier.wosid | 000359323100003 | - |
dc.identifier.scopusid | 2-s2.0-84938828539 | - |
dc.type.rims | ART | - |
dc.citation.volume | 29 | - |
dc.citation.issue | 15 | - |
dc.citation.beginningpage | 1599 | - |
dc.citation.endingpage | 1604 | - |
dc.citation.publicationname | GENES & DEVELOPMENT | - |
dc.identifier.doi | 10.1101/gad.263749.115 | - |
dc.contributor.localauthor | Song, Ji-Joon | - |
dc.contributor.nonIdAuthor | Yoon, Je-Hyun | - |
dc.contributor.nonIdAuthor | Jo, Myung Hyun | - |
dc.contributor.nonIdAuthor | White, Elizabeth J. F. | - |
dc.contributor.nonIdAuthor | De, Supriyo | - |
dc.contributor.nonIdAuthor | Hafner, Markus | - |
dc.contributor.nonIdAuthor | Zucconi, Beth E. | - |
dc.contributor.nonIdAuthor | Abdelmohsen, Kotb | - |
dc.contributor.nonIdAuthor | Martindale, Jennifer L. | - |
dc.contributor.nonIdAuthor | Yang, Xiaoling | - |
dc.contributor.nonIdAuthor | Wood, William H., III | - |
dc.contributor.nonIdAuthor | Shin, Yu Mi | - |
dc.contributor.nonIdAuthor | Tuschl, Thomas | - |
dc.contributor.nonIdAuthor | Becker, Kevin G. | - |
dc.contributor.nonIdAuthor | Wilson, Gerald M. | - |
dc.contributor.nonIdAuthor | Hohng, Sungchul | - |
dc.contributor.nonIdAuthor | Gorospe, Myriam | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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