cis-{Pt(NH3)(2)(L)}(2+/+) (L = Cl, H2O, NH3) binding to purines and CO: Does pi-back-donation play a role?

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The ability of cis-{Pt(NH3)(2)(L)}(2+/+), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-{Pt(NH3)(2)(L)}(2+/+) (L = Cl, H2O, NH3) is a poor g-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.
Publisher
AMER CHEMICAL SOC
Issue Date
2003-12
Language
English
Article Type
Article
Keywords

NONCLASSICAL METAL-CARBONYLS; INTRASTRAND CROSS-LINK; AB-INITIO; VIBRATIONAL SPECTRA; STRETCHING REGION; CISPLATIN BINDING; INFRARED SPECTRA; MAJOR ADDUCT; DNA-ADDUCTS; GUANINE

Citation

INORGANIC CHEMISTRY, v.42, no.26, pp.8615 - 8617

ISSN
0020-1669
DOI
10.1021/ic035022b
URI
http://hdl.handle.net/10203/203362
Appears in Collection
CH-Journal Papers(저널논문)
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