Heat shock protein X purified from Mycobacterium tuberculosis enhances the efficacy of dendritic cells-based immunotherapy for the treatment of allergic asthma

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Dendritic cells play an important role in determining whether naive T cells mature into either Th1 or Th2 cells. We determined whether heat-shock protein X (HspX) purified from Mycobacterium tuberculosis regulates the Th1/Th2 immune response in an ovalbumin (OVA)-induced murine model of asthma. HspX increased interferon-gamma, IL-17A, -12 and transforming growth factor (TGF)-beta production and T-bet gene expression but reduced IL-13 production and GATA-3 gene expression. HspX also inhibited asthmatic reactions as demonstrated by an increase in the number of eosinophils in bronchoalveolar lavage fluid, inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyper-responsiveness. Furthermore, HspX enhanced OVA-induced decrease of regulatory T cells in the mediastinal lymph nodes. This study provides evidence that HspX plays critical roles in the amelioration of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of HspX with respect to its effects on a murine model of asthma.
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Issue Date
2015-03
Language
English
Article Type
Article
Keywords

T-BET; TRANSCRIPTION FACTOR; LINEAGE COMMITMENT; HUMAN GATA-3; INFLAMMATION; TH1; PATHOGENESIS; EXPRESSION; HYPERRESPONSIVENESS; EOSINOPHILS

Citation

BMB REPORTS, v.48, no.3, pp.178 - 183

ISSN
1976-6696
DOI
10.5483/BMBRep.2015.48.3.257
URI
http://hdl.handle.net/10203/202922
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