DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, JW | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Lavillette, D | ko |
dc.contributor.author | Cosset, FL | ko |
dc.contributor.author | Yang, SH | ko |
dc.contributor.author | Lee, CG | ko |
dc.contributor.author | Jin, HT | ko |
dc.contributor.author | Kim, CM | ko |
dc.contributor.author | Shata, MTM | ko |
dc.contributor.author | Lee, DH | ko |
dc.contributor.author | Pfahler, W | ko |
dc.contributor.author | Prince, AM | ko |
dc.contributor.author | Sung, YC | ko |
dc.date.accessioned | 2015-11-20T10:28:44Z | - |
dc.date.available | 2015-11-20T10:28:44Z | - |
dc.date.created | 2014-10-02 | - |
dc.date.created | 2014-10-02 | - |
dc.date.issued | 2005-12 | - |
dc.identifier.citation | HEPATOLOGY, v.42, no.6, pp.1429 - 1436 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201433 | - |
dc.description.abstract | Immune correlates of protection against hepatitis C virus (HCV) infection are not well understood. Here we investigated 2 naive and 6 immunized chimpanzees before and after intravenous challenge, 12 weeks after the last immunization, with 100 50% chimpanzee infectious doses (CID50) of heterologous genotype 1b HCV. Vaccination with recombinant DNA and adenovirus vaccines expressing HCV core, E1E2, and NS3-5 genes induced long-term HCV-specific antibody and T-cell responses and reduced peak viral load about 100 times compared with controls (5.91 +/- 0.38 vs. 3.81 +/- 0.71 logs, respectively). There was a statistically significant inverse correlation between peak viral loads and envelope glycoprotein 2 (E2)-specific antibody responses at the time of challenge. Interestingly, one vaccinee that had sterilizing immunity against slightly heterologous virus generated the highest level of E2-specific total and neutralizing antibody responses as well as strong NS3/NS5-specific T-cell proliferative responses. The other four vaccinees with low levels of E2-specific antibody had about 44-fold reduced peak viral loads but eventually developed persistent infections. In conclusion, vaccine-induced E2-specific antibody plays an important role in prevention from nonhomologous virus infection and may provide new insight into the development of an effective HCV vaccine. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | STIMULATING FACTOR GENE | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.subject | DNA IMMUNIZATION | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | ENVELOPE PROTEIN | - |
dc.subject | VACCINATION | - |
dc.subject | VACCINES | - |
dc.subject | REPLICATION | - |
dc.subject | MACROPHAGES | - |
dc.title | Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee | - |
dc.type | Article | - |
dc.identifier.wosid | 000233697400027 | - |
dc.identifier.scopusid | 2-s2.0-32944465532 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1429 | - |
dc.citation.endingpage | 1436 | - |
dc.citation.publicationname | HEPATOLOGY | - |
dc.identifier.doi | 10.1002/hep.20934 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Youn, JW | - |
dc.contributor.nonIdAuthor | Lavillette, D | - |
dc.contributor.nonIdAuthor | Cosset, FL | - |
dc.contributor.nonIdAuthor | Yang, SH | - |
dc.contributor.nonIdAuthor | Lee, CG | - |
dc.contributor.nonIdAuthor | Jin, HT | - |
dc.contributor.nonIdAuthor | Kim, CM | - |
dc.contributor.nonIdAuthor | Shata, MTM | - |
dc.contributor.nonIdAuthor | Lee, DH | - |
dc.contributor.nonIdAuthor | Pfahler, W | - |
dc.contributor.nonIdAuthor | Prince, AM | - |
dc.contributor.nonIdAuthor | Sung, YC | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | STIMULATING FACTOR GENE | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | DNA IMMUNIZATION | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | ENVELOPE PROTEIN | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.subject.keywordPlus | VACCINES | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.