Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers
A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.
- Publisher
- WILEY-BLACKWELL
- Issue Date
- 2012-01
- Language
- English
- Article Type
- Article
- Keywords
MESOPOROUS SILICA NANOPARTICLES; CIRCULATING TUMOR-CELLS; CHEMISTRY; BINDING; SURFACE; RECOGNITION; COMPLEXES; PLATFORM; TARGETS; ASSAYS
- Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.51, no.2, pp.450 - 454
- ISSN
- 1433-7851
- Appears in Collection
- BS-Journal Papers(저널논문)
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