DC Field | Value | Language |
---|---|---|
dc.contributor.author | 도민재 | ko |
dc.contributor.author | 김규리 | ko |
dc.contributor.author | 이해신 | ko |
dc.contributor.author | 차세호 | ko |
dc.contributor.author | 박희정 | ko |
dc.contributor.author | 이정순 | ko |
dc.contributor.author | 김태일 | ko |
dc.date.accessioned | 2015-11-20T10:19:51Z | - |
dc.date.available | 2015-11-20T10:19:51Z | - |
dc.date.created | 2014-02-05 | - |
dc.date.created | 2014-02-05 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | Journal of Periodontal & Implant Science, v.43, no.4, pp.147 - 152 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201333 | - |
dc.description.abstract | Purpose: An animal periodontitis model is essential for research on the pathogenesis and treatment of periodontal disease. In this study, we have introduced a lipopolysaccharide (LPS) of a periodontal pathogen to the alveolar bone defect of experimental animals and investigated its suitability as a periodontitis model. Methods: Alveolar bone defects were made in both sides of the mandibular third premolar region of nine beagle dogs. Then,the animals were divided into the following groups: silk ligature tied on the cervical region of tooth group, Porphyromonas gingivalis LPS (P.g. LPS)-saturated collagen with silk ligature group, and no ligature or P.g. LPS application group as the control. The plaque index and gingival index were measured at 0 and 4 weeks postoperatively. The animals were then euthanized and prepared for histologic evaluation. Results: The silk ligature group and P.g. LPS with silk ligature group showed a significantly higher plaque index at 4 weeks compared to the control (P<0.05). No significant difference was found in the plaque index between the silk ligature group and P.g. LPS with silk ligature group. The P.g. LPS with silk ligature group showed a significantly higher gingival index compared to the silk ligature group or the control at 4 weeks (P<0.05). Histologic examination presented increased inflammatory cell infiltration in the gingival tissue and alveolar bone of the P.g. LPS with silk ligature group. Conclusions: An additional P.g. LPS-saturated collagen with silk ligature ensured periodontal inflammation at 4 weeks. Therefore, P.g. LPS with silk ligature application to surgically created alveolar bone defects may be a candidate model for experimental periodontitis. | - |
dc.language | Korean | - |
dc.publisher | 대한치주과학회 | - |
dc.title | Development of animal experimental periodontitis models | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-84884518484 | - |
dc.type.rims | ART | - |
dc.citation.volume | 43 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 147 | - |
dc.citation.endingpage | 152 | - |
dc.citation.publicationname | Journal of Periodontal & Implant Science | - |
dc.identifier.kciid | ART001797988 | - |
dc.contributor.localauthor | 이해신 | - |
dc.contributor.nonIdAuthor | 도민재 | - |
dc.contributor.nonIdAuthor | 김규리 | - |
dc.contributor.nonIdAuthor | 차세호 | - |
dc.contributor.nonIdAuthor | 박희정 | - |
dc.contributor.nonIdAuthor | 이정순 | - |
dc.contributor.nonIdAuthor | 김태일 | - |
dc.subject.keywordAuthor | Animal models | - |
dc.subject.keywordAuthor | Lipopolysaccharides | - |
dc.subject.keywordAuthor | Periodontitis | - |
dc.subject.keywordAuthor | Porphyromonas gingivalis | - |
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