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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

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dc.contributor.authorChoi, Won Ilko
dc.contributor.authorKamaly, Nazilako
dc.contributor.authorRiol-Blanco, Lorenako
dc.contributor.authorLee, In-Hyunko
dc.contributor.authorWu, Junko
dc.contributor.authorSwami, Archanako
dc.contributor.authorVilos, Cristianko
dc.contributor.authorYameen, Basitko
dc.contributor.authorYu, Mikyungko
dc.contributor.authorShi, Jinjunko
dc.contributor.authorTabas, Irako
dc.contributor.authorvon Andrian, Ulrich H.ko
dc.contributor.authorJon, Sangyongko
dc.contributor.authorFarokhzad, Omid C.ko
dc.date.accessioned2015-11-20T09:50:52Z-
dc.date.available2015-11-20T09:50:52Z-
dc.date.created2014-12-24-
dc.date.created2014-12-24-
dc.date.issued2014-11-
dc.identifier.citationNANO LETTERS, v.14, no.11, pp.6449 - 6455-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10203/201122-
dc.description.abstractProtein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectRAW 264.7 MACROPHAGES-
dc.subjectTHERAPEUTIC PROTEINS-
dc.subjectDRUG-DELIVERY-
dc.subjectIN-VIVO-
dc.subjectPOLYMERIC NANOPARTICLES-
dc.subjectLIPID NANOPARTICLES-
dc.subjectINSULIN-
dc.subjectEXPRESSION-
dc.subjectCARRIERS-
dc.subjectINTERLEUKIN-10-
dc.titleA Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins-
dc.typeArticle-
dc.identifier.wosid000345723800066-
dc.identifier.scopusid2-s2.0-84910010660-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue11-
dc.citation.beginningpage6449-
dc.citation.endingpage6455-
dc.citation.publicationnameNANO LETTERS-
dc.identifier.doi10.1021/nl502994y-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.nonIdAuthorChoi, Won Il-
dc.contributor.nonIdAuthorKamaly, Nazila-
dc.contributor.nonIdAuthorRiol-Blanco, Lorena-
dc.contributor.nonIdAuthorLee, In-Hyun-
dc.contributor.nonIdAuthorWu, Jun-
dc.contributor.nonIdAuthorSwami, Archana-
dc.contributor.nonIdAuthorVilos, Cristian-
dc.contributor.nonIdAuthorYameen, Basit-
dc.contributor.nonIdAuthorYu, Mikyung-
dc.contributor.nonIdAuthorShi, Jinjun-
dc.contributor.nonIdAuthorTabas, Ira-
dc.contributor.nonIdAuthorvon Andrian, Ulrich H.-
dc.contributor.nonIdAuthorFarokhzad, Omid C.-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorNanopartilces-
dc.subject.keywordAuthorthermosponge-
dc.subject.keywordAuthorsolvent-free-
dc.subject.keywordAuthortherapeutic proteins-
dc.subject.keywordAuthorbiologics-
dc.subject.keywordPlusRAW 264.7 MACROPHAGES-
dc.subject.keywordPlusTHERAPEUTIC PROTEINS-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusPOLYMERIC NANOPARTICLES-
dc.subject.keywordPlusLIPID NANOPARTICLES-
dc.subject.keywordPlusINSULIN-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCARRIERS-
dc.subject.keywordPlusINTERLEUKIN-10-
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