A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

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Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Publisher
AMER CHEMICAL SOC
Issue Date
2014-11
Language
English
Article Type
Article
Keywords

RAW 264.7 MACROPHAGES; THERAPEUTIC PROTEINS; DRUG-DELIVERY; IN-VIVO; POLYMERIC NANOPARTICLES; LIPID NANOPARTICLES; INSULIN; EXPRESSION; CARRIERS; INTERLEUKIN-10

Citation

NANO LETTERS, v.14, no.11, pp.6449 - 6455

ISSN
1530-6984
DOI
10.1021/nl502994y
URI
http://hdl.handle.net/10203/201122
Appears in Collection
BS-Journal Papers(저널논문)
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