DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, Young Sik | ko |
dc.contributor.author | Shin, Ho-Chul | ko |
dc.contributor.author | Park, Wei Sun | ko |
dc.contributor.author | Ge, Jianning | ko |
dc.contributor.author | Kim, Chan-Hee | ko |
dc.contributor.author | Lee, Bok Luel | ko |
dc.contributor.author | Heo, Won-Do | ko |
dc.contributor.author | Jung, Jae U. | ko |
dc.contributor.author | Rigden, Daniel John | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.date.accessioned | 2015-11-20T09:06:29Z | - |
dc.date.available | 2015-11-20T09:06:29Z | - |
dc.date.created | 2015-05-06 | - |
dc.date.created | 2015-05-06 | - |
dc.date.created | 2015-05-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | PLOS ONE, v.10, no.3 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201010 | - |
dc.description.abstract | Legionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery. Some of these proteins have been shown to manipulate or subvert cellular processes during infection, but functional roles of a majority of them remain unknown. Lpg0393 is a newly identified Legionella effector classified as a hypothetical protein. Through X-ray crystallographic analysis, we show that Lpg0393 contains a Vps9-like domain, which is structurally most similar to the catalytic core of human Rabex-5 that activates the endosomal Rab proteins Rab5, Rab21 and Rab22. Consistently, Lpg0393 exhibited a guanine-nucleotide exchange factor activity toward the endosomal Rabs. This work identifies the first example of a bacterial guanine-nucleotide exchange factor that is active towards the Rab5 sub-cluster members, implying that the activation of these Rab proteins might be advantageous for the intracellular survival of Legionella. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22 | - |
dc.type | Article | - |
dc.identifier.wosid | 000352134700022 | - |
dc.identifier.scopusid | 2-s2.0-84926429927 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 3 | - |
dc.citation.publicationname | PLOS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0118683 | - |
dc.contributor.localauthor | Heo, Won-Do | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Park, Wei Sun | - |
dc.contributor.nonIdAuthor | Ge, Jianning | - |
dc.contributor.nonIdAuthor | Kim, Chan-Hee | - |
dc.contributor.nonIdAuthor | Lee, Bok Luel | - |
dc.contributor.nonIdAuthor | Jung, Jae U. | - |
dc.contributor.nonIdAuthor | Rigden, Daniel John | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EFFECTOR PROTEIN DRRA | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | GTPASE FUNCTION | - |
dc.subject.keywordPlus | X-RAY | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RABEX-5 | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | VPS9 | - |
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