DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bersini, S. | ko |
dc.contributor.author | Jeon, Jessie Sungyun | ko |
dc.contributor.author | Moretti, Matteo | ko |
dc.contributor.author | Kamm, R. D. | ko |
dc.date.accessioned | 2015-11-20T07:42:06Z | - |
dc.date.available | 2015-11-20T07:42:06Z | - |
dc.date.created | 2015-08-05 | - |
dc.date.created | 2015-08-05 | - |
dc.date.created | 2015-08-05 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | DRUG DISCOVERY TODAY, v.19, no.6, pp.735 - 742 | - |
dc.identifier.issn | 1359-6446 | - |
dc.identifier.uri | http://hdl.handle.net/10203/200830 | - |
dc.description.abstract | A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | BREAST-CANCER METASTASIS | - |
dc.subject | SIALYL-LEWIS-X | - |
dc.subject | TUMOR-CELLS | - |
dc.subject | TRANSENDOTHELIAL MIGRATION | - |
dc.subject | MICROFLUIDIC DEVICE | - |
dc.subject | LEUKOCYTE ADHESION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | LUNG METASTASIS | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | BONE | - |
dc.title | In vitro models of the metastatic cascade: from local invasion to extravasation | - |
dc.type | Article | - |
dc.identifier.wosid | 000337882200005 | - |
dc.identifier.scopusid | 2-s2.0-84902080037 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 735 | - |
dc.citation.endingpage | 742 | - |
dc.citation.publicationname | DRUG DISCOVERY TODAY | - |
dc.identifier.doi | 10.1016/j.drudis.2013.12.006 | - |
dc.contributor.localauthor | Jeon, Jessie Sungyun | - |
dc.contributor.nonIdAuthor | Bersini, S. | - |
dc.contributor.nonIdAuthor | Moretti, Matteo | - |
dc.contributor.nonIdAuthor | Kamm, R. D. | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | BREAST-CANCER METASTASIS | - |
dc.subject.keywordPlus | SIALYL-LEWIS-X | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | MICROFLUIDIC DEVICE | - |
dc.subject.keywordPlus | LEUKOCYTE ADHESION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | LUNG METASTASIS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | BONE | - |
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