DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Byung Hyun | ko |
dc.contributor.author | Min, Hye Sook | ko |
dc.contributor.author | Lee, You Jeong | ko |
dc.contributor.author | Choi, Bomi | ko |
dc.contributor.author | Kim, Eun Ji | ko |
dc.contributor.author | Lee, Jonghoon | ko |
dc.contributor.author | Kim, Jeong-Rae | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.contributor.author | Kim, Tae Jin | ko |
dc.contributor.author | Jung, Kyeong Cheon | ko |
dc.contributor.author | Park, Seong Hoe | ko |
dc.date.accessioned | 2015-11-20T07:37:19Z | - |
dc.date.available | 2015-11-20T07:37:19Z | - |
dc.date.created | 2014-12-30 | - |
dc.date.created | 2014-12-30 | - |
dc.date.created | 2014-12-30 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.47 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/200780 | - |
dc.description.abstract | Analysis of the T-cell receptor (TCR) repertoire of innate CD4(+) T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4(+) T cells) is essential for predicting the characteristics of the antigens that bind to these T cells and for distinguishing T-T CD4(+) T cells from other types of innate T cells. Using the TCRmini Tg mouse model, we show that the repertoire of TCR alpha chains in T-T CD4(+) T cells was extremely diverse, in contrast to the repertoires previously described for other types of innate T cells. The TCR alpha chain sequences significantly overlapped between T-T CD4(+) T cells and conventional CD4(+) T cells in the thymus and spleen. However, the diversity of the TCR alpha repertoire of T-T CD4(+) T cells seemed to be restricted compared with that of conventional CD4(+) T cells. Interestingly, the frequency of the parental OT-II TCR alpha chains was significantly reduced in the process of T-T interaction. This diverse and shifted repertoire in T-T CD4(+) T cells has biological relevance in terms of defense against diverse pathogens and a possible regulatory role during peripheral T-T interaction. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Analyses of the TCR repertoire of MHC class II-restricted innate CD4(+) T cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000358592900011 | - |
dc.identifier.scopusid | 2-s2.0-84965191423 | - |
dc.type.rims | ART | - |
dc.citation.volume | 47 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.1038/emm.2015.7 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Kang, Byung Hyun | - |
dc.contributor.nonIdAuthor | Min, Hye Sook | - |
dc.contributor.nonIdAuthor | Lee, You Jeong | - |
dc.contributor.nonIdAuthor | Choi, Bomi | - |
dc.contributor.nonIdAuthor | Kim, Eun Ji | - |
dc.contributor.nonIdAuthor | Lee, Jonghoon | - |
dc.contributor.nonIdAuthor | Kim, Jeong-Rae | - |
dc.contributor.nonIdAuthor | Kim, Tae Jin | - |
dc.contributor.nonIdAuthor | Jung, Kyeong Cheon | - |
dc.contributor.nonIdAuthor | Park, Seong Hoe | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject.keywordPlus | POSITIVE SELECTION | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | SELF-PEPTIDES | - |
dc.subject.keywordPlus | ALPHA-CHAIN | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
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