The relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment

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dc.contributor.authorKim, Tae-Eunko
dc.contributor.authorLee, Dong Hyunko
dc.contributor.authorKim, Yoon-Jeongko
dc.contributor.authorMok, Ji Ohko
dc.contributor.authorKim, Chul-Heeko
dc.contributor.authorPakr, Jeong-Hoko
dc.contributor.authorLee, Tae-Kyeongko
dc.contributor.authorYoo, Kwangsunko
dc.contributor.authorJeong, Yongko
dc.contributor.authorLee, Yunhwanko
dc.contributor.authorPark, Sun Ahko
dc.date.accessioned2015-07-22T04:53:01Z-
dc.date.available2015-07-22T04:53:01Z-
dc.date.created2014-07-27-
dc.date.created2014-07-27-
dc.date.created2014-07-27-
dc.date.issued2015-06-
dc.identifier.citationINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v.30, no.6, pp.551 - 557-
dc.identifier.issn0885-6230-
dc.identifier.urihttp://hdl.handle.net/10203/200010-
dc.description.abstract"Objective: Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR.Methods: This study included 85 consecutive non-diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). Cognitive performances were analyzed as a function of scores on the HOMA-IR.Results: The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA-IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT-I) (r=-0.244, p =0.026) and Controlled Oral Word Association Test (COWAT) (r =-0.270, p =0.013). In subgroup analysis by APOE status, SVLT-delayed (p=0.027) and COWAT (p =0.016) scores were found to be significantly lower in the IR than the non-IR among those with APOE epsilon 4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA-IR (beta =-0.271, t =-2.340, p =0.022). However, IR status was identified to interact with APOE epsilon 4 carriership toward poor performances in the COWAT (beta =-0.335, t =-2.285, p=0.026).Conclusion: This study found a domain-specific impact of HOMA-IR scores on cognitive performances in non-diabetic patients with MCI. This association was profound only in APOE epsilon 4 carriers. Copyright (C) 2014 John Wiley & Sons, Ltd."-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.titleThe relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment-
dc.typeArticle-
dc.identifier.wosid000355985600001-
dc.identifier.scopusid2-s2.0-84929047802-
dc.type.rimsART-
dc.citation.volume30-
dc.citation.issue6-
dc.citation.beginningpage551-
dc.citation.endingpage557-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY-
dc.identifier.doi10.1002/gps.4181-
dc.contributor.localauthorJeong, Yong-
dc.contributor.nonIdAuthorKim, Tae-Eun-
dc.contributor.nonIdAuthorLee, Dong Hyun-
dc.contributor.nonIdAuthorKim, Yoon-Jeong-
dc.contributor.nonIdAuthorMok, Ji Oh-
dc.contributor.nonIdAuthorKim, Chul-Hee-
dc.contributor.nonIdAuthorPakr, Jeong-Ho-
dc.contributor.nonIdAuthorLee, Tae-Kyeong-
dc.contributor.nonIdAuthorLee, Yunhwan-
dc.contributor.nonIdAuthorPark, Sun Ah-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorapolipoprotein E-
dc.subject.keywordAuthormild cognitive impairment-
dc.subject.keywordAuthorinsulin resistance-
dc.subject.keywordPlusFASTING PLASMA-GLUCOSE-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusGEOMETRICALLY ACCURATE-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusRISK-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordPlusATROPHY-
dc.subject.keywordPlusSEGMENTATION-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusDEMENTIA-
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