DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Eun | ko |
dc.contributor.author | Lee, Dong Hyun | ko |
dc.contributor.author | Kim, Yoon-Jeong | ko |
dc.contributor.author | Mok, Ji Oh | ko |
dc.contributor.author | Kim, Chul-Hee | ko |
dc.contributor.author | Pakr, Jeong-Ho | ko |
dc.contributor.author | Lee, Tae-Kyeong | ko |
dc.contributor.author | Yoo, Kwangsun | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Lee, Yunhwan | ko |
dc.contributor.author | Park, Sun Ah | ko |
dc.date.accessioned | 2015-07-22T04:53:01Z | - |
dc.date.available | 2015-07-22T04:53:01Z | - |
dc.date.created | 2014-07-27 | - |
dc.date.created | 2014-07-27 | - |
dc.date.created | 2014-07-27 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v.30, no.6, pp.551 - 557 | - |
dc.identifier.issn | 0885-6230 | - |
dc.identifier.uri | http://hdl.handle.net/10203/200010 | - |
dc.description.abstract | "Objective: Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR.Methods: This study included 85 consecutive non-diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). Cognitive performances were analyzed as a function of scores on the HOMA-IR.Results: The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA-IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT-I) (r=-0.244, p =0.026) and Controlled Oral Word Association Test (COWAT) (r =-0.270, p =0.013). In subgroup analysis by APOE status, SVLT-delayed (p=0.027) and COWAT (p =0.016) scores were found to be significantly lower in the IR than the non-IR among those with APOE epsilon 4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA-IR (beta =-0.271, t =-2.340, p =0.022). However, IR status was identified to interact with APOE epsilon 4 carriership toward poor performances in the COWAT (beta =-0.335, t =-2.285, p=0.026).Conclusion: This study found a domain-specific impact of HOMA-IR scores on cognitive performances in non-diabetic patients with MCI. This association was profound only in APOE epsilon 4 carriers. Copyright (C) 2014 John Wiley & Sons, Ltd." | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | The relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment | - |
dc.type | Article | - |
dc.identifier.wosid | 000355985600001 | - |
dc.identifier.scopusid | 2-s2.0-84929047802 | - |
dc.type.rims | ART | - |
dc.citation.volume | 30 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 551 | - |
dc.citation.endingpage | 557 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | - |
dc.identifier.doi | 10.1002/gps.4181 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.nonIdAuthor | Kim, Tae-Eun | - |
dc.contributor.nonIdAuthor | Lee, Dong Hyun | - |
dc.contributor.nonIdAuthor | Kim, Yoon-Jeong | - |
dc.contributor.nonIdAuthor | Mok, Ji Oh | - |
dc.contributor.nonIdAuthor | Kim, Chul-Hee | - |
dc.contributor.nonIdAuthor | Pakr, Jeong-Ho | - |
dc.contributor.nonIdAuthor | Lee, Tae-Kyeong | - |
dc.contributor.nonIdAuthor | Lee, Yunhwan | - |
dc.contributor.nonIdAuthor | Park, Sun Ah | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | apolipoprotein E | - |
dc.subject.keywordAuthor | mild cognitive impairment | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordPlus | FASTING PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | GEOMETRICALLY ACCURATE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | SEGMENTATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | DEMENTIA | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.