DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, S | ko |
dc.contributor.author | Na, HS | ko |
dc.contributor.author | Kim, J | ko |
dc.contributor.author | Lee, J | ko |
dc.contributor.author | Lee, S | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Park, J | ko |
dc.contributor.author | Chen, Chien-Chang | ko |
dc.contributor.author | Campbell, Kevin P. | ko |
dc.contributor.author | Shin, Hee-Sup | ko |
dc.date.accessioned | 2010-11-16T02:27:38Z | - |
dc.date.available | 2010-11-16T02:27:38Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.citation | GENES BRAIN AND BEHAVIOR, v.6, no.5, pp.425 - 431 | - |
dc.identifier.issn | 1601-1848 | - |
dc.identifier.uri | http://hdl.handle.net/10203/19996 | - |
dc.description.abstract | Although T-type Ca2+ channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility in mice lacking Ca(V)3.2 subtype of T-type Ca2+ channels (Ca(V)3.2(-/-)) with wild-type littermates in various behavioral models of pain to explore the roles of Ca(V)3.2 in the processing of noxious stimuli in vivo. In acute mechanical, thermal and chemical pain tests, Ca(V)3.2(-/-) mice showed decreased pain responses compared to wild-type mice. Ca(V)3.2(-/-) mice also displayed attenuated pain responses to tonic noxious stimuli such as intraperitoneal injections of irritant agents and intradermal injections of formalin. In spinal nerve ligation-induced neuropathic pain, however, behavioral responses of Ca(V)3.2(-/-) mice were not different from those of wild-type mice. The present study reveals that the Ca(V)3.2 subtype of T-type Ca2+ channels are important in the peripheral processing of noxious signals, regardless of modality, duration or affected tissue type. | - |
dc.description.sponsorship | We thank Joonoh Park and Jaeseong Park for mice care, and Hannah Seong for the analysis of pain behaviors. This work was supported by the Chemoinformatics Program and the Center-of- Excellence program of the Korea Institute of Science and Technology, and in part by a grant (M103KV010009 03K220100910) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Republic of Korea. K.P.C. is an investigator of the Howard Hughes Medical Institute. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Wiley-Blackwell | - |
dc.subject | ROOT GANGLION NEURONS | - |
dc.subject | CALCIUM-CHANNEL | - |
dc.subject | CA2+ CHANNELS | - |
dc.subject | NEUROPATHIC PAIN | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | AFFERENT NEURONS | - |
dc.subject | REDOX MODULATION | - |
dc.subject | FORMALIN TEST | - |
dc.subject | GENE FAMILY | - |
dc.subject | EXPRESSION | - |
dc.title | Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels | - |
dc.type | Article | - |
dc.identifier.wosid | 000247667000003 | - |
dc.identifier.scopusid | 2-s2.0-33947540792 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 425 | - |
dc.citation.endingpage | 431 | - |
dc.citation.publicationname | GENES BRAIN AND BEHAVIOR | - |
dc.identifier.doi | 10.1111/j.1601-183X.2006.00268.x | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Choi, S | - |
dc.contributor.nonIdAuthor | Na, HS | - |
dc.contributor.nonIdAuthor | Kim, J | - |
dc.contributor.nonIdAuthor | Lee, J | - |
dc.contributor.nonIdAuthor | Lee, S | - |
dc.contributor.nonIdAuthor | Park, J | - |
dc.contributor.nonIdAuthor | Chen, Chien-Chang | - |
dc.contributor.nonIdAuthor | Campbell, Kevin P. | - |
dc.contributor.nonIdAuthor | Shin, Hee-Sup | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | chemical pain | - |
dc.subject.keywordAuthor | mechanical pain | - |
dc.subject.keywordAuthor | neuropathic pain | - |
dc.subject.keywordAuthor | spinal nerve ligation ( SNL) | - |
dc.subject.keywordAuthor | thermal pain | - |
dc.subject.keywordAuthor | tonic inflammatory pain | - |
dc.subject.keywordPlus | ROOT GANGLION NEURONS | - |
dc.subject.keywordPlus | CALCIUM-CHANNEL | - |
dc.subject.keywordPlus | CA2+ CHANNELS | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | AFFERENT NEURONS | - |
dc.subject.keywordPlus | REDOX MODULATION | - |
dc.subject.keywordPlus | FORMALIN TEST | - |
dc.subject.keywordPlus | GENE FAMILY | - |
dc.subject.keywordPlus | EXPRESSION | - |
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