Network of hypothalamic neurons that control appetite

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dc.contributor.authorSohn, Jong-Wooko
dc.date.accessioned2015-06-29T04:46:09Z-
dc.date.available2015-06-29T04:46:09Z-
dc.date.created2014-12-31-
dc.date.created2014-12-31-
dc.date.created2014-12-31-
dc.date.issued2015-04-
dc.identifier.citationBMB REPORTS, v.48, no.4, pp.229 - 233-
dc.identifier.issn1976-6696-
dc.identifier.urihttp://hdl.handle.net/10203/199479-
dc.description.abstractThe central nervous system (CNS) controls food intake and energy expenditure via tight coordinations between multiple neuronal populations. Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetite-increasing) neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons. The coordinated regulation of neuronal circuit involving these neurons is essential in properly maintaining energy balance, and any disturbance therein may result in hyperphagia/obesity or hypophagia/starvation. Thus, adequate knowledge of the POMC and NPY/AgRP neuron physiology is mandatory to understand the pathophysiology of obesity and related metabolic diseases. This review will discuss the history and recent updates on the POMC and NPY/AgRP neuronal circuits, as well as the general anorexigenic and orexigenic circuits in the CNS.-
dc.languageEnglish-
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY-
dc.subjectARCUATE PROOPIOMELANOCORTIN NEURONS-
dc.subjectENERGY HOMEOSTASIS-
dc.subjectPOMC NEURONS-
dc.subjectPARAVENTRICULAR NUCLEUS-
dc.subjectPARABRACHIAL NUCLEUS-
dc.subjectGLUCOSE-HOMEOSTASIS-
dc.subjectREGULATE ENERGY-
dc.subjectAGRP NEURONS-
dc.subjectMELANOCORTIN PATHWAYS-
dc.subjectFEEDING-BEHAVIOR-
dc.titleNetwork of hypothalamic neurons that control appetite-
dc.typeArticle-
dc.identifier.wosid000355185300007-
dc.identifier.scopusid2-s2.0-84929318780-
dc.type.rimsART-
dc.citation.volume48-
dc.citation.issue4-
dc.citation.beginningpage229-
dc.citation.endingpage233-
dc.citation.publicationnameBMB REPORTS-
dc.identifier.doi10.5483/BMBRep.2015.48.4.272-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorSohn, Jong-Woo-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthorGABA-
dc.subject.keywordAuthorNeuronal circuit-
dc.subject.keywordAuthorNPY/AgRP neuron-
dc.subject.keywordAuthorPOMC neuron-
dc.subject.keywordAuthoralpha-MSH-
dc.subject.keywordAuthorGABA-
dc.subject.keywordAuthorNeuronal circuit-
dc.subject.keywordAuthorNPY/AgRP neuron-
dc.subject.keywordAuthorPOMC neuron-
dc.subject.keywordAuthoralpha-MSH-
dc.subject.keywordPlusARCUATE PROOPIOMELANOCORTIN NEURONS-
dc.subject.keywordPlusENERGY HOMEOSTASIS-
dc.subject.keywordPlusPOMC NEURONS-
dc.subject.keywordPlusPARAVENTRICULAR NUCLEUS-
dc.subject.keywordPlusPARABRACHIAL NUCLEUS-
dc.subject.keywordPlusGLUCOSE-HOMEOSTASIS-
dc.subject.keywordPlusREGULATE ENERGY-
dc.subject.keywordPlusAGRP NEURONS-
dc.subject.keywordPlusMELANOCORTIN PATHWAYS-
dc.subject.keywordPlusFEEDING-BEHAVIOR-
dc.subject.keywordPlusARCUATE PROOPIOMELANOCORTIN NEURONS-
dc.subject.keywordPlusENERGY HOMEOSTASIS-
dc.subject.keywordPlusPOMC NEURONS-
dc.subject.keywordPlusPARAVENTRICULAR NUCLEUS-
dc.subject.keywordPlusPARABRACHIAL NUCLEUS-
dc.subject.keywordPlusGLUCOSE-HOMEOSTASIS-
dc.subject.keywordPlusREGULATE ENERGY-
dc.subject.keywordPlusAGRP NEURONS-
dc.subject.keywordPlusMELANOCORTIN PATHWAYS-
dc.subject.keywordPlusFEEDING-BEHAVIOR-
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