Biodistribution and clearance of aminoclay nanoparticles: implication for in vivo applicability as a tailor-made drug delivery carrier

Cited 31 time in webofscience Cited 0 time in scopus
  • Hit : 403
  • Download : 0
3-Aminopropyl functionalized magnesium phyllosilicate (aminoclay) is a tailor-made organoclay material that has many biomedical applications. Defining the biodistribution and in vivo pharmacokinetics of aminoclay is essential to gauge the therapeutic potential of aminoclay. Therefore, the present study investigated the in vivo fate of aminoclay nanoparticles in a mouse model. Fluorescent Cy5.0-conjugated-aminoclay (Cy5.0-aminoclay) was synthesized for optical imaging and quantification in vivo and then its tissue distribution as well as elimination pathways was investigated in mice. After intravenous administration, fast tissue distribution of Cy5.0-aminoclay into various organs including the liver, kidney, lung, heart, and intestine was evident, as was the rapid clearance from each organ without any long-term accumulation. In addition, systemically administered nanoparticles were eliminated mainly from the urine and feces, where the nearly complete recovery of administered dose was achieved within 72 h. After oral administration, the biodistribution and pharmacokinetic studies indicated no intestinal absorption of Cy5.0-aminoclay. Consequently, about 90% of orally administered nanoparticles were eliminated via feces within 24 h. Taken all together, the present study highlights the low risk for long-term tissue accumulation of aminoclay particles, which may be desirable attributes for biomedical applications as a drug delivery carrier.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2014-11
Language
English
Article Type
Article
Keywords

FUNCTIONALIZED MAGNESIUM PHYLLOSILICATES; ORGANOCLAY BUILDING-BLOCKS; LAMELLAR NANOCOMPOSITES; HALLOYSITE NANOTUBES; SILICA NANOPARTICLES; FE-AMINOCLAY; FILMS; CLAY; PH; SIZE

Citation

JOURNAL OF MATERIALS CHEMISTRY B, v.2, no.43, pp.7567 - 7574

ISSN
2050-750X
DOI
10.1039/c4tb00953c
URI
http://hdl.handle.net/10203/199074
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 31 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0