DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jongshin | ko |
dc.contributor.author | Jo, Haiin | ko |
dc.contributor.author | Hong, Hyowon | ko |
dc.contributor.author | Kim, Min Hwan | ko |
dc.contributor.author | Kim, Jin Man | ko |
dc.contributor.author | Lee, June Koo | ko |
dc.contributor.author | Heo, Won-Do | ko |
dc.contributor.author | Kim, Joon | ko |
dc.date.accessioned | 2015-06-04T01:45:10Z | - |
dc.date.available | 2015-06-04T01:45:10Z | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.created | 2015-06-01 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/198759 | - |
dc.description.abstract | Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking | - |
dc.type | Article | - |
dc.identifier.wosid | 000353702500021 | - |
dc.identifier.scopusid | 2-s2.0-84926642096 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms7781 | - |
dc.contributor.localauthor | Heo, Won-Do | - |
dc.contributor.localauthor | Kim, Joon | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | PRIMARY CILIUM | - |
dc.subject.keywordPlus | GROWTH-CONTROL | - |
dc.subject.keywordPlus | CELL-SHAPE | - |
dc.subject.keywordPlus | TAZ | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NEK1 | - |
dc.subject.keywordPlus | YAP | - |
dc.subject.keywordPlus | ACTIVATION | - |
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