Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

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dc.contributor.authorKim, Jong Inko
dc.contributor.authorHuh, Jin Youngko
dc.contributor.authorSohn, Jee Hyungko
dc.contributor.authorChoe, Sung Sikko
dc.contributor.authorLee, Yun Sokko
dc.contributor.authorLim, Chun Yanko
dc.contributor.authorJo, Alako
dc.contributor.authorPark, Seung Bumko
dc.contributor.authorHan, Weipingko
dc.contributor.authorKim, Jae Bumko
dc.date.accessioned2015-05-22T02:30:54Z-
dc.date.available2015-05-22T02:30:54Z-
dc.date.created2015-05-20-
dc.date.created2015-05-20-
dc.date.issued2015-05-
dc.identifier.citationMOLECULAR AND CELLULAR BIOLOGY, v.35, no.10, pp.1686 - 1699-
dc.identifier.issn0270-7306-
dc.identifier.urihttp://hdl.handle.net/10203/198594-
dc.description.abstractIn obesity, adipocyte hypertrophy and proinflammatory responses are closely associated with the development of insulin resistance in adipose tissue. However, it is largely unknown whether adipocyte hypertrophy per se might be sufficient to provoke insulin resistance in obese adipose tissue. Here, we demonstrate that lipid-overloaded hypertrophic adipocytes are insulin resistant independent of adipocyte inflammation. Treatment with saturated or monounsaturated fatty acids resulted in adipocyte hypertrophy, but proinflammatory responses were observed only in adipocytes treated with saturated fatty acids. Regardless of adipocyte inflammation, hypertrophic adipocytes with large and unilocular lipid droplets exhibited impaired insulin-dependent glucose uptake, associated with defects in GLUT4 trafficking to the plasma membrane. Moreover, Toll-like receptor 4 mutant mice (C3H/HeJ) with high-fat-diet-induced obesity were not protected against insulin resistance, although they were resistant to adipose tissue inflammation. Together, our in vitro and in vivo data suggest that adipocyte hypertrophy alone may be crucial in causing insulin resistance in obesity.-
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.subjectADIPOSE-TISSUE INFLAMMATION-
dc.subjectHIGH-FAT DIET-
dc.subjectGLUCOSE TRANSPORTER-
dc.subject3T3-L1 ADIPOCYTES-
dc.subjectTNF-ALPHA-
dc.subjectCELL-SIZE-
dc.subjectIKK-BETA-
dc.subjectOBESITY-
dc.subjectMICE-
dc.subjectEXPRESSION-
dc.titleLipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation-
dc.typeArticle-
dc.identifier.wosid000353310200003-
dc.identifier.scopusid2-s2.0-84929223982-
dc.type.rimsART-
dc.citation.volume35-
dc.citation.issue10-
dc.citation.beginningpage1686-
dc.citation.endingpage1699-
dc.citation.publicationnameMOLECULAR AND CELLULAR BIOLOGY-
dc.identifier.doi10.1128/MCB.01321-14-
dc.contributor.localauthorLee, Yun Sok-
dc.contributor.nonIdAuthorKim, Jong In-
dc.contributor.nonIdAuthorHuh, Jin Young-
dc.contributor.nonIdAuthorSohn, Jee Hyung-
dc.contributor.nonIdAuthorChoe, Sung Sik-
dc.contributor.nonIdAuthorLim, Chun Yan-
dc.contributor.nonIdAuthorJo, Ala-
dc.contributor.nonIdAuthorPark, Seung Bum-
dc.contributor.nonIdAuthorHan, Weiping-
dc.contributor.nonIdAuthorKim, Jae Bum-
dc.type.journalArticleArticle-
dc.subject.keywordPlusADIPOSE-TISSUE INFLAMMATION-
dc.subject.keywordPlusHIGH-FAT DIET-
dc.subject.keywordPlusGLUCOSE TRANSPORTER-
dc.subject.keywordPlus3T3-L1 ADIPOCYTES-
dc.subject.keywordPlusTNF-ALPHA-
dc.subject.keywordPlusCELL-SIZE-
dc.subject.keywordPlusIKK-BETA-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusEXPRESSION-
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