DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hye-Hyun | ko |
dc.contributor.author | Lee, Kyu-Hee | ko |
dc.contributor.author | Lee, Doyun | ko |
dc.contributor.author | Han, Young-Eun | ko |
dc.contributor.author | Lee, Suk-Ho | ko |
dc.contributor.author | Sohn, Jong Woo | ko |
dc.contributor.author | Ho, Won-Kyung | ko |
dc.date.accessioned | 2015-05-22T02:23:49Z | - |
dc.date.available | 2015-05-22T02:23:49Z | - |
dc.date.created | 2015-04-27 | - |
dc.date.created | 2015-04-27 | - |
dc.date.created | 2015-04-27 | - |
dc.date.created | 2015-04-27 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, v.35, no.16, pp.6401 - 6412 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10203/198576 | - |
dc.description.abstract | Glutamate, a major neurotransmitter in the brain, activates ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs, respectively). The two types of glutamate receptors interact with each other, as exemplified by the modulation of iGluRs by mGluRs. However, the other way of interaction (i.e., modulation of mGluRs by iGluRs) has not received much attention. In this study, we found that group I mGluR-specific agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) alone is not sufficient to activate phospholipase C (PLC) in rat hippocampus, while glutamate robustly activates PLC. These results suggested that additional mechanisms provided by iGluRs are involved in group I mGluR-mediated PLC activation. A series of experiments demonstrated that glutamate-induced PLC activation is mediated by mGluR5 and is facilitated by local Ca2+ signals that are induced by AMPA-mediated depolarization and L-type Ca2+ channel activation. Finally, we found that PLC and L-type Ca2+ channels are involved in hippocampal mGluR-dependent long-term depression (mGluR-LTD) induced by paired-pulse low-frequency stimulation, but not in DHPG-induced chemical LTD. Together, we propose that AMPA receptors initiate Ca2+ influx via the L-type Ca2+ channels that facilitate mGluR-5-PLC signaling cascades, which underlie mGluRLTD in rat hippocampus. | - |
dc.language | English | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.title | Costimulation of AMPA and Metabotropic Glutamate Receptors Underlies Phospholipase C Activation by Glutamate in Hippocampus | - |
dc.type | Article | - |
dc.identifier.wosid | 000353399800014 | - |
dc.identifier.scopusid | 2-s2.0-84929379131 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 16 | - |
dc.citation.beginningpage | 6401 | - |
dc.citation.endingpage | 6412 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE | - |
dc.identifier.doi | 10.1523/JNEUROSCI.4208-14.2015 | - |
dc.contributor.localauthor | Sohn, Jong Woo | - |
dc.contributor.nonIdAuthor | Kim, Hye-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Kyu-Hee | - |
dc.contributor.nonIdAuthor | Lee, Doyun | - |
dc.contributor.nonIdAuthor | Han, Young-Eun | - |
dc.contributor.nonIdAuthor | Lee, Suk-Ho | - |
dc.contributor.nonIdAuthor | Ho, Won-Kyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Cav1.2 | - |
dc.subject.keywordAuthor | Cav1.3 | - |
dc.subject.keywordAuthor | confocal imaging | - |
dc.subject.keywordAuthor | electrophysiology | - |
dc.subject.keywordAuthor | local calcium | - |
dc.subject.keywordAuthor | mGluR-LTD | - |
dc.subject.keywordAuthor | Cav1.2 | - |
dc.subject.keywordAuthor | Cav1.3 | - |
dc.subject.keywordAuthor | confocal imaging | - |
dc.subject.keywordAuthor | electrophysiology | - |
dc.subject.keywordAuthor | local calcium | - |
dc.subject.keywordAuthor | mGluR-LTD | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | BACKPROPAGATING ACTION-POTENTIALS | - |
dc.subject.keywordPlus | CEREBELLAR GRANULE CELLS | - |
dc.subject.keywordPlus | CA1 PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | RAT HIPPOCAMPUS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | SYNAPTIC ACTIVATION | - |
dc.subject.keywordPlus | DISTINCT FORMS | - |
dc.subject.keywordPlus | CHO-CELLS | - |
dc.subject.keywordPlus | CA2+ | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | BACKPROPAGATING ACTION-POTENTIALS | - |
dc.subject.keywordPlus | CEREBELLAR GRANULE CELLS | - |
dc.subject.keywordPlus | CA1 PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | RAT HIPPOCAMPUS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | SYNAPTIC ACTIVATION | - |
dc.subject.keywordPlus | DISTINCT FORMS | - |
dc.subject.keywordPlus | CHO-CELLS | - |
dc.subject.keywordPlus | CA2+ | - |
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