DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Sung Soo | ko |
dc.contributor.author | Kim, Min | ko |
dc.contributor.author | Youn, Byoung-Soo | ko |
dc.contributor.author | Lee, Nam Seok | ko |
dc.contributor.author | Park, Ji Woo | ko |
dc.contributor.author | Lee, In Kyu | ko |
dc.contributor.author | Lee, Yun Sok | ko |
dc.contributor.author | Kim, Jae Bum | ko |
dc.contributor.author | Cho, Young Min | ko |
dc.contributor.author | Lee, Hong Kyu | ko |
dc.contributor.author | Park, Kyong Soo | ko |
dc.date.accessioned | 2015-04-29T02:32:22Z | - |
dc.date.available | 2015-04-29T02:32:22Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOLOGY, v.29, no.1, pp.20 - 30 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | http://hdl.handle.net/10203/198375 | - |
dc.description.abstract | Oxidative stress plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus and in diabetic vascular complications. Thiazolidinediones (TZDs), a class of peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists, improve insulin sensitivity and are currently used for the treatment of type 2 diabetes mellitus. Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling. Importantly, TZD-mediated activation of PPAR gamma induces gene expression of glutathione peroxidase 3 (GPx3), which reduces extracellular H(2)O(2) levels causing insulin resistance in skeletal muscle cells. Inhibition of GPx3 expression prevents the antioxidant effects of TZDs on insulin action in oxidative stress-induced insulin-resistant cells, suggesting that GPx3 is required for the regulation of PPAR gamma-mediated antioxidant effects. Furthermore, reduced plasma GPx3 levels were found in patients with type 2 diabetes mellitus and in db/db/DIO mice. Collectively, these results suggest that the antioxidant effect of PPAR gamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus. | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.subject | INDUCED INSULIN-RESISTANCE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | MICROMOLAR CONCENTRATIONS | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | PLASMA | - |
dc.subject | EXPRESSION | - |
dc.subject | TISSUE | - |
dc.subject | GENE | - |
dc.title | Glutathione Peroxidase 3 Mediates the Antioxidant Effect of Peroxisome Proliferator-Activated Receptor gamma in Human Skeletal Muscle Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000261697500001 | - |
dc.identifier.scopusid | 2-s2.0-58149464712 | - |
dc.type.rims | ART | - |
dc.citation.volume | 29 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 20 | - |
dc.citation.endingpage | 30 | - |
dc.citation.publicationname | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.identifier.doi | 10.1128/MCB.00544-08 | - |
dc.contributor.localauthor | Lee, Yun Sok | - |
dc.contributor.nonIdAuthor | Chung, Sung Soo | - |
dc.contributor.nonIdAuthor | Kim, Min | - |
dc.contributor.nonIdAuthor | Youn, Byoung-Soo | - |
dc.contributor.nonIdAuthor | Lee, Nam Seok | - |
dc.contributor.nonIdAuthor | Park, Ji Woo | - |
dc.contributor.nonIdAuthor | Lee, In Kyu | - |
dc.contributor.nonIdAuthor | Kim, Jae Bum | - |
dc.contributor.nonIdAuthor | Cho, Young Min | - |
dc.contributor.nonIdAuthor | Lee, Hong Kyu | - |
dc.contributor.nonIdAuthor | Park, Kyong Soo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MICROMOLAR CONCENTRATIONS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | GENE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.