DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yun Sok | ko |
dc.contributor.author | Kim, Jung-whan | ko |
dc.contributor.author | Osborne, Olivia | ko |
dc.contributor.author | Oh, Da Young | ko |
dc.contributor.author | Sasik, Roman | ko |
dc.contributor.author | Schenk, Simon | ko |
dc.contributor.author | Chen, Ai | ko |
dc.contributor.author | Chung, Heekyung | ko |
dc.contributor.author | Murphy, Anne | ko |
dc.contributor.author | Watkins, Steven M. | ko |
dc.contributor.author | Quehenberger, O | ko |
dc.contributor.author | Johnson, Randall S. | ko |
dc.contributor.author | Olefsky, Jerrold M. | ko |
dc.date.accessioned | 2015-04-29T02:29:36Z | - |
dc.date.available | 2015-04-29T02:29:36Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.created | 2015-01-06 | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | CELL, v.157, no.6, pp.1339 - 1352 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/198363 | - |
dc.description.abstract | Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger HIF-1 alpha induction, setting off the chronic adipose tissue inflammatory response characteristic of obesity. At the molecular level, these events involve saturated fatty acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane protein, which leads to the uncoupled respiratory state. Genetic or pharmacologic inhibition of either ANT2 or HIF-1 alpha can prevent or reverse these pathophysiologic events, restoring a state of insulin sensitivity and glucose tolerance. These results reveal the sequential series of events in obesity-induced inflammation and insulin resistance. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | ADENINE-NUCLEOTIDE TRANSLOCASE | - |
dc.subject | WHITE ADIPOSE-TISSUE | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | MITOCHONDRIAL RESPIRATION | - |
dc.subject | ENERGY-EXPENDITURE | - |
dc.subject | HYPOXIA | - |
dc.subject | MICE | - |
dc.subject | FAT | - |
dc.subject | MACROPHAGES | - |
dc.subject | INHIBITION | - |
dc.title | Increased Adipocyte O-2 Consumption Triggers HIF-1 alpha, Causing Inflammation and Insulin Resistance in Obesity | - |
dc.type | Article | - |
dc.identifier.wosid | 000340881400011 | - |
dc.identifier.scopusid | 2-s2.0-84902075318 | - |
dc.type.rims | ART | - |
dc.citation.volume | 157 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1339 | - |
dc.citation.endingpage | 1352 | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/j.cell.2014.05.012 | - |
dc.contributor.localauthor | Lee, Yun Sok | - |
dc.contributor.nonIdAuthor | Kim, Jung-whan | - |
dc.contributor.nonIdAuthor | Osborne, Olivia | - |
dc.contributor.nonIdAuthor | Oh, Da Young | - |
dc.contributor.nonIdAuthor | Sasik, Roman | - |
dc.contributor.nonIdAuthor | Schenk, Simon | - |
dc.contributor.nonIdAuthor | Chen, Ai | - |
dc.contributor.nonIdAuthor | Chung, Heekyung | - |
dc.contributor.nonIdAuthor | Murphy, Anne | - |
dc.contributor.nonIdAuthor | Watkins, Steven M. | - |
dc.contributor.nonIdAuthor | Quehenberger, O | - |
dc.contributor.nonIdAuthor | Johnson, Randall S. | - |
dc.contributor.nonIdAuthor | Olefsky, Jerrold M. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ADENINE-NUCLEOTIDE TRANSLOCASE | - |
dc.subject.keywordPlus | WHITE ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | MITOCHONDRIAL RESPIRATION | - |
dc.subject.keywordPlus | ENERGY-EXPENDITURE | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | INHIBITION | - |
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