This paper addresses a neural network guidance based on pursuit-evasion games, and performance enhancing methods for it. Two-dimensional pursuit-evasion games solved by the gradient-based method are considered. The neural network guidance law employs the range, range rate, line-of-sight rate, and heading error as its input variables. Additional pattern selection methods and a hybrid guidance method are proposed for the sake of the interception performance enhancement. Numerical simulations are accompanied for the verification of the neural network approximation, and of the improved interception performance by the proposed methods. Moreover, all proposed guidance laws are compared with proportional navigation. (c) 2005 Elsevier Ltd. All rights reserved.