System-level identification of cellular functions underlying human's high-order brain function based on functional module-centric transcriptome analysis기능모듈 중심의 전사체 분석을 통한 인간 고등뇌기능 연관 세포 기능의 시스템적 발굴

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 680
  • Download : 0
Identification of molecular mechanisms underlying human’s high-order brain functions and its dysfunction is a fundamental component of successful drug development for related diseases. Despite many neurobiological studies, yet molecular mechanisms are largely unknown to comprehensively account for the complex phenotypes especially in human. Although advent of bioinformatics analysis based on transcriptome data enables us to efficiently discover candidate molecular components, human brain analysis may require additional sensitivity to the tran-scriptomic change of cellular functions for the following reasons. First, the high-order brain functions are enormously complex, which makes it necessary to decipher system-level mechanisms rather than few single molecules. Second, the type and extent of dysfunction in, for example cognition, is highly heterogeneous between individuals even with the same disease and in vivo human brain transcriptome data is relatively rare due to the difficulty of sampling and quality control. Considering these, I performed two inter-related researches in two different directions to identify the extensive cellular functions that are associated with human’s high-order brain functions and dysfunction by analyzing two different human brain transcriptome data with a sensitivity-enhanced bioinformatics approach. First, I carried out a comparative transcriptomic analysis of human and chimpanzee cerebral cortex to identify extensive cellular functions uniquely associated with human’s pronounced pheno-typic characteristics such as enhanced cognition and vulnerability to neurodegenerative diseases and psychiatric disorders. Differently from previous studies, I measured activity change of functional modules rather than individual genes by analyzing change of modular gene expression and of intra-module coexpression between species. I showed that the intra-module coexpression change analysis most extensively identified changes of functional modules c...
Advisors
Yi, Gwan-Suresearcher이관수
Description
한국과학기술원 : 정보통신공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
586460/325007  / 020058004
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 정보통신공학과, 2013.2, [ viii, 94 p. ]

Keywords

high-order human brain function; 인지기능저하; 공동발현; 기능모듈; 전사체; 인간 고등뇌기능; transcriptome; functional module; cognitive dysfunction; coexpression

URI
http://hdl.handle.net/10203/197791
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=586460&flag=dissertation
Appears in Collection
ICE-Theses_Ph.D.(박사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0