Discovery of context-specific patterns for biomedical information = 바이오의료 정보를 위한 상황특이적 패턴 발굴기술

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Biomedical information is combined information between biological information and medical information. This biomedical information covers varying levels of units from the molecule level to the phenotype level. The introduction of omics data, including genomics, transcriptomics, proteomics, and metabolomics, made an integrated systematic analysis possible on biological phenomena. Hence, current biomedical information means multi-level relation data from numerous experiments. Electronic medical records data about patients’ information and other text data on biomedical literature are also included as biomedical data.Biomedical relations occur at specific conditions. According to recent research, each phase of a cell shows a different pattern of activated relations and every disease has various patterns of activated and deactivated relations. In addition, each gene expression shows context-specific patterns according to the kind of drugs used. Thus, understanding the variety of patterns under different conditions is essential to infer actual phenomena. Biomedical information needs an especially deep understanding of the dynamics of biomedical patterns under different conditions to derive effective treatments in various conditions. Previously, research aimed to discover biomedical patterns under specific conditions, but this research was not accurate enough to predict biomedical patterns under various conditions. A more accurate and automated methodology is needed to figure out context-specific patterns. Furthermore, an automated context interpretation method for given biomedical patterns should be developed.To ameliorate this situation, we suggested a methodology that discovers specific patterns in a specific context, as well as an automated context interpretation method for given patterns. We considered the context of disease and usages of drugs from primary biomedical information including experimental and reported text data to investigate relations between cont...
Advisors
Lee, Kwang-Hyungresearcher이광형Lee, Do-Heon이도헌
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
561916/325007  / 020087054
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2013.8, [ ix, 101 p. ]

Keywords

drugs; biomedical information; 상황특이패턴; 질병; 약; 바이오의료정보; context-specific patterns; diseases

URI
http://hdl.handle.net/10203/196344
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=561916&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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