Modulation of neuronal activity using photothermal stimulation of gold nanorod = 나노 금막대의 열자극을 이용한 신경세포의 전기적 활동의 조절

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The ability to switch the neuronal activity in a spatio-temporally controllable means provides the opportunity to understand the intricately linked information in the brain. Recently, optical tool is able to control from neural network operating to organism behavior by stimulating the genetically programmed nerve cells. However, optical approaches have limits in low penetrability of the visible light, necessity of gene transfection and photothermal damages. Here, this study demonstrates that neuronal firing could be effectively modulated through the advanced phoththermal stimulation. In order to minimize the light absorption by the cell, near infrared was used as a photothermal energy source. And gold nanorod was optimized for absorbing the near infrared, which converted to thermal energy on the nanorod surfaces. Toxicity of gold nanorod was settled by surface coating with polyelectrolytes. Using the photothermal stimuli, this study found that neural firing rate could be modulated by suppressing the neuron activity and it could be suppressed up to 100% with high reproducibility and long-term stability. This study represents high performance and possibility to be a new class of stimulation method. Thus, it could be applied to many neuroscientific researches and disorder therapeutics.
Advisors
Nam, Yoon-Keyresearcher남윤기
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2012
Identifier
568085/325007  / 020103398
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2012.2, [ 145 p. ]

Keywords

Nanoparticle; 광유전학; 억제; 자극; 신경 해마세포; 나노입자; Hippocampal neuron; Stimulation; Suppression; Optogenetics

URI
http://hdl.handle.net/10203/196316
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=568085&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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