Mapping intrinsic functional connectivity using large-scale voltage-sensitive dye imaging in anesthetized mice = 전압민감성 염료 영상법을 이용한 마취된 쥐의 안정시 기능적 연결망의 매핑

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Despite of the enthusiasm towards intrinsic functional connectivity observed in the brain at rest, currently available approaches to study iFC are limited due to a number of technical limitations. First, the brain imaging modalities such as fMRI, EEG and MEG have either poor temporal resolution or spatial resolution, limiting the way of analysis. This has lead fMRI studies to focus on the spatial patterns of activations at rest, whereas EEG and MEG studies exploited the temporal information embedded in signals within diverse frequency ranges. This is partly due to volume conduction, which makes it harder to study the spatial patterns in EEG and MEG. Second, it is hard to couple these modalities in animal models that allow powerful genetic and molecular approaches, along with diverse invasive experimental methods. To overcome these limitations, large-scale voltage-sensitive dye imaging has been performed in mice cortex, revealing the spatiotemporal details of the neuronal activities that were unable to observe in other modalities. However, previous studies relied on visual inspection and counting to analyze the dynamics of the activities. In this study, I performed large-scale voltage-sensitive dye imaging in urethane anesthetized mice that offer functional signals with high spatiotemporal resolution, but without volume conduction effect. I then applied network analysis such as spatial independent component analysis that was able to couple the spatial information and temporal information of the functional networks within diverse frequency ranges, describing the activity level changes at network level. This enabled me to investigate the dynamics of intrinsic functional connectivity with superior spatiotemporal resolution while maximizing the amount of information under analysis. I propose that this approach can bridge the gap between human and animal studies as well as providing a useful platform to investigate the brain dynamics. This platform could also be use...
Jeong, Yongresearcher정용
한국과학기술원 : 바이오및뇌공학과,
Issue Date
566279/325007  / 020114288

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2013.8, [ iv, 29 p. ]


Intrinsic functional connectivity; 안정시 뇌 활동; 독립요인분석; 시공간적 해상도; 전압민감성 염료를 이용한 이미징; 내인적 연결성; large-scale voltage-sensitive dye imaging; spatiotemporal resolution; spatial independent component analysis; spontaneous brain activity

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