Intracellular delivery of pH- and reduction sensitive nanogel for cancer cell = pH와 환원 반응 민감성 나노겔의 암세포 내 전달

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This study was conducted to develop a drug delivery carrier with specific drug release profile to-wards tumor cells based on the fact that tumor cells have lower pH and higher concentration of a reducing agent than normal cells. Hydrazone bond was used as a pH sensitive linker that is stable at pH 7.4 but unsta-ble at pH 5.0. Doxorubicin (DOX) was conjugated on poly(aspartyl hydrazide) (PAHy) backbone with hydra-zone bond. N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) crosslinker grafted on the backbone formed a disulfide bond in a normal cell, but the disulfide bond was dissociated in a tumor cell. In a normal cell drugs were released with only disregarded amount, but in a tumor cell, drugs were rapidly released as a consequence of breaking of hydrazone bonds and disulfide bonds. Characterization of the dual sensitive particle was fully investigated. The specific drug release profile under tumor condition and anticancer therapeutic effect was also evaluated.
Advisors
Kim, Jong-Dukresearcher김종득
Description
한국과학기술원 : 생명화학공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
586415/325007  / 020114319
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2013.8, [ viii, 58p ]

Keywords

drug delivery carrier; pH와 환원 이중 민감성; 폴리머-약물 접합체; 아미노산 유도체; 약물전달체; cancer treatment; poly(amino acid)s; polymer-drug conjugates; H and reduction dual sensitivity

URI
http://hdl.handle.net/10203/196281
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=586415&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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