Role of T-type calcium channel on tremorogenesis = T-type 칼슘 채널에 의한 진전증 생성 기작 연구

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Tremor is a rhythmic muscle contraction that has been implicated in physiological and pathological functions of brain; however, the neural pacemaker underlying tremor rhythm remains obscure. Here, we investigate the role of T-type calcium channel on tremorogenesis, by using two models of essential tremor and mice lacking CaV3.1 T-type calcium channel. In harmaline-induced tremor model, potentiation of CaV3.1 is critical on the generation of 4-10Hz tremor rhythm in the inferior olive. In GABA-A α1 subunit knockout tremor model, however, absence of CaV3.1 enhances tremor by inducing 20-25Hz tremor-related oscillation in motor cortex; thus, T-type calcium channel is critical for pacemaking tremor rhythm and its way of contribution depends on the acting brain area. Our findings cast light on the molecular mechanism of tremorogenesis, proposing T-type calcium channel as a new therapeutic target of essential tremor.
Advisors
Kim, Dae-Sooresearcher김대수
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2011
Identifier
567199/325007  / 020068012
Language
eng
Description

한국과학기술원 : 생명과학과, 한국과학기술원 : 생명과학과, 2011., [ i, 84 p. ]

Keywords

가바; 하말린; 티타입 칼슘채널; 진전증파동; 진전증; Harmaline; T-type calcium channel; Tremor rhythm; Tremor; GABA-A alpha 1 subunit

URI
http://hdl.handle.net/10203/196206
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=567199&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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