Nanoplasmonic Biopatch for in vivo Surface Enhanced Raman Spectroscopy

Cited 10 time in webofscience Cited 10 time in scopus
  • Hit : 453
  • Download : 0
Surfaced enhanced Raman scattering (SERS) has been extensively exploited for label-free and non-destructive biochemical detections. Recently diverse SERS substrates have been reported to improve sensitivity of SERS. However, the current platforms still have technical limitation for in vivo applications. Here, we report a nanoplasmonic biopatch of plasmonic nanoparticles physically embedded in highly biocompatible and Raman inactive agarose hydrogel. Molecular diffusion of small molecules such as neurotransmitter through nanoplasmonic biopatch was quantitatively visualized without labeling by using real-time microscopic SERS. In particular, the nano/micro porous structures within agarose hydrogel allow the SERS detection of macromolecules such as amyloid fibrils. This soft SERS platform opens up new opportunities for in vivo SERS applications.
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Issue Date
2014-12
Language
English
Article Type
Article
Citation

BIOCHIP JOURNAL, v.8, no.4, pp.289 - 294

ISSN
1976-0280
DOI
10.1007/s13206-014-8407-5
URI
http://hdl.handle.net/10203/195496
Appears in Collection
BiS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 10 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0