DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soh, Young Min | ko |
dc.contributor.author | Buermann, Frank | ko |
dc.contributor.author | Shin, Ho-Chul | ko |
dc.contributor.author | Oda, Takashi | ko |
dc.contributor.author | Jin, Kyeong Sik | ko |
dc.contributor.author | Toseland, Christopher P. | ko |
dc.contributor.author | Kim, Cheolhee | ko |
dc.contributor.author | Lee, Hansol | ko |
dc.contributor.author | Kim, Soo Jin | ko |
dc.contributor.author | Kong, Min-Seok | ko |
dc.contributor.author | Durand-Diebold, Marie-Laure | ko |
dc.contributor.author | Kim, Yeon-Gil | ko |
dc.contributor.author | Kim, Ho-Min | ko |
dc.contributor.author | Lee, Nam Ki | ko |
dc.contributor.author | Sato, Mamoru | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Stephan Gruber | ko |
dc.date.accessioned | 2015-04-08T02:27:18Z | - |
dc.date.available | 2015-04-08T02:27:18Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | MOLECULAR CELL, v.57, no.2, pp.290 - 303 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195458 | - |
dc.description.abstract | SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge'' dimerization domain with an ATP-regulated "head'' dimerization module. Here, we address the structural arrangement of the long coiled coils in SMC complexes. We unequivocally show that prokaryotic Smc-ScpAB, eukaryotic condensin, and possibly also cohesin form rod-like structures, with their coiled coils being closely juxtaposed and accurately anchored to the hinge. Upon ATP-induced binding of DNA to the hinge, however, Smc switches to a more open configuration. Our data suggest that a long-distance structural transition is transmitted from the Smc head domains to regulate Smc-ScpAB's association with DNA. These findings uncover a conserved architectural theme in SMC complexes, provide a mechanistic basis for Smc's dynamic engagement with chromosomes, and offer a molecular explanation for defects in Cornelia de Lange syndrome. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | X-RAY-SCATTERING | - |
dc.subject | HINGE DOMAIN | - |
dc.subject | CHROMOSOME CONDENSATION | - |
dc.subject | FUNCTIONAL IMPLICATIONS | - |
dc.subject | STRUCTURAL MAINTENANCE | - |
dc.subject | BACILLUS-SUBTILIS | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | ATP HYDROLYSIS | - |
dc.subject | COMPLEX | - |
dc.title | Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding | - |
dc.type | Article | - |
dc.identifier.wosid | 000348507800009 | - |
dc.identifier.scopusid | 2-s2.0-84921445757 | - |
dc.type.rims | ART | - |
dc.citation.volume | 57 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 290 | - |
dc.citation.endingpage | 303 | - |
dc.citation.publicationname | MOLECULAR CELL | - |
dc.identifier.doi | 10.1016/j.molcel.2014.11.023 | - |
dc.contributor.localauthor | Kim, Ho-Min | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Buermann, Frank | - |
dc.contributor.nonIdAuthor | Oda, Takashi | - |
dc.contributor.nonIdAuthor | Jin, Kyeong Sik | - |
dc.contributor.nonIdAuthor | Toseland, Christopher P. | - |
dc.contributor.nonIdAuthor | Kim, Cheolhee | - |
dc.contributor.nonIdAuthor | Kong, Min-Seok | - |
dc.contributor.nonIdAuthor | Durand-Diebold, Marie-Laure | - |
dc.contributor.nonIdAuthor | Kim, Yeon-Gil | - |
dc.contributor.nonIdAuthor | Lee, Nam Ki | - |
dc.contributor.nonIdAuthor | Sato, Mamoru | - |
dc.contributor.nonIdAuthor | Stephan Gruber | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | X-RAY-SCATTERING | - |
dc.subject.keywordPlus | HINGE DOMAIN | - |
dc.subject.keywordPlus | CHROMOSOME CONDENSATION | - |
dc.subject.keywordPlus | FUNCTIONAL IMPLICATIONS | - |
dc.subject.keywordPlus | STRUCTURAL MAINTENANCE | - |
dc.subject.keywordPlus | BACILLUS-SUBTILIS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ATP HYDROLYSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
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