Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering

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dc.contributor.authorSambudi, Nonni Sorayako
dc.contributor.authorSathya Murthy, Madhaviko
dc.contributor.authorLee, Gyun-Minko
dc.contributor.authorPark, Seung-Binko
dc.date.accessioned2015-04-07T05:03:35Z-
dc.date.available2015-04-07T05:03:35Z-
dc.date.created2014-12-16-
dc.date.created2014-12-16-
dc.date.issued2015-01-
dc.identifier.citationCOMPOSITES SCIENCE AND TECHNOLOGY, v.106, pp.76 - 84-
dc.identifier.issn0266-3538-
dc.identifier.urihttp://hdl.handle.net/10203/195263-
dc.description.abstractThe role of CaCO3 nanoparticles as a reinforcing agent in increasing the mechanical properties of electrospun chitosan/poly(vinyl alcohol) (PVA) is inspired by the incorporation of CaCO3 inside a chitin network in nature. The loading concentration of CaCO3 nanoparticles varied from 1 to 5 wt%, and the diameter of fibers ranges from 71.5 +/- 23.4 nm to 140.7 +/- 15.1 nm with an increased loading of CaCO3. A tensile test on 4 wt% CaCO3-reinforced fibers revealed a Young's modulus up to 912.5 +/- 60.6 MPa from 15.7 +/- 3 MPa, which is almost sixty times the value of fibers without CaCO3. The biocompatibilities of the CaCO3-loaded fibers were also tested in a 14-day simulated body fluid (SBF) incubation to induce the formation of apatite minerals and in a 14-day cell proliferation assay with ATDC5 cells. The chitosan/PVA-CaCO3 (4 wt%) was found to provide the most suitable environment for cell growth in comparison with chitosan/PVA and chitosan/PVA-apatite. The CaCO3-reinforced chitosan/PVA has potential to be a promising alternative as an artificial cartilage. (C) 2014 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectGUIDED BONE REGENERATION-
dc.subjectCOMPOSITES-
dc.subjectCHITOSAN-
dc.subjectHYDROXYAPATITE-
dc.subjectFIBERS-
dc.subjectNANOCOMPOSITES-
dc.subjectNANOFIBERS-
dc.subjectSCAFFOLDS-
dc.subjectCELLS-
dc.subjectBIOMATERIALS-
dc.titleElectrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering-
dc.typeArticle-
dc.identifier.wosid000347868200007-
dc.identifier.scopusid2-s2.0-84911876810-
dc.type.rimsART-
dc.citation.volume106-
dc.citation.beginningpage76-
dc.citation.endingpage84-
dc.citation.publicationnameCOMPOSITES SCIENCE AND TECHNOLOGY-
dc.identifier.doi10.1016/j.compscitech.2014.11.003-
dc.contributor.localauthorLee, Gyun-Min-
dc.contributor.localauthorPark, Seung-Bin-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorNano particles-
dc.subject.keywordAuthorParticle-reinforced composites-
dc.subject.keywordAuthorMechanical properties-
dc.subject.keywordAuthorElectro-spinning-
dc.subject.keywordPlusGUIDED BONE REGENERATION-
dc.subject.keywordPlusCOMPOSITES-
dc.subject.keywordPlusCHITOSAN-
dc.subject.keywordPlusHYDROXYAPATITE-
dc.subject.keywordPlusFIBERS-
dc.subject.keywordPlusNANOCOMPOSITES-
dc.subject.keywordPlusNANOFIBERS-
dc.subject.keywordPlusSCAFFOLDS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusBIOMATERIALS-
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