DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zheng, Jian | ko |
dc.contributor.author | Piao, Mei Jing | ko |
dc.contributor.author | Kim, Ki Cheon | ko |
dc.contributor.author | Yao, Cheng Wen | ko |
dc.contributor.author | Cha, Ji Won | ko |
dc.contributor.author | Shin, Jennifer Hyunjong | ko |
dc.contributor.author | Yoo, Suk Jae | ko |
dc.contributor.author | Hyun, Jin Won | ko |
dc.date.accessioned | 2015-04-07T04:51:00Z | - |
dc.date.available | 2015-04-07T04:51:00Z | - |
dc.date.created | 2015-02-09 | - |
dc.date.created | 2015-02-09 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.38, no.3, pp.891 - 900 | - |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195221 | - |
dc.description.abstract | Excessive ultraviolet (UV) radiation, a constituent of sunlight, can induce multiple types of skin damage. We recently demonstrated that americanin B, a lignin compound, protected cells against hydrogen peroxide (H2O2)-induced damage by exerting antioxidant effects and inhibiting apoptosis. In this study, we investigated the ability of americanin B to protect against cell injury induced by UVB (280-320 nm), the most harmful UV wavelengths, in human HaCaT keratinocytes. Americanin B absorbed UVB, eliminated UVB-induced intracellular reactive oxygen species (ROS), and decreased the extent of UVB -induced oxidative modification of lipids, proteins, and DNA. In addition, americanin B inhibited UVB-induced apoptosis, as indicated by reductions in apoptotic body formation and DNA fragmentation. Furthermore, americanin B reversed the depolarization of the mitochondrial membrane induced by LIVE exposure. These protective activities were associated with down-regulation of apoptosis-promoting proteins, Bax, caspase-9, and caspase-3 and up-regulation of an apoptosis inhibitor, Bcl-2. These results suggest that americanin B can protect human keratinocytes against UVB-induced cell damage. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | UVB-INDUCED APOPTOSIS | - |
dc.subject | HUMAN DERMAL FIBROBLAST | - |
dc.subject | INDUCED DNA-DAMAGE | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | SKIN KERATINOCYTES | - |
dc.subject | OXIDATIVE DAMAGE | - |
dc.subject | HACAT CELLS | - |
dc.subject | IRRADIATION | - |
dc.subject | RADIATION | - |
dc.subject | INFLAMMATION | - |
dc.title | Photo-protective effect of americanin B against ultraviolet B-induced damage in cultured human keratinocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000347512400022 | - |
dc.identifier.scopusid | 2-s2.0-84908616765 | - |
dc.type.rims | ART | - |
dc.citation.volume | 38 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 891 | - |
dc.citation.endingpage | 900 | - |
dc.citation.publicationname | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | - |
dc.identifier.doi | 10.1016/j.etap.2014.08.017 | - |
dc.contributor.localauthor | Shin, Jennifer Hyunjong | - |
dc.contributor.nonIdAuthor | Zheng, Jian | - |
dc.contributor.nonIdAuthor | Piao, Mei Jing | - |
dc.contributor.nonIdAuthor | Kim, Ki Cheon | - |
dc.contributor.nonIdAuthor | Yao, Cheng Wen | - |
dc.contributor.nonIdAuthor | Cha, Ji Won | - |
dc.contributor.nonIdAuthor | Yoo, Suk Jae | - |
dc.contributor.nonIdAuthor | Hyun, Jin Won | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Americanin B | - |
dc.subject.keywordAuthor | Ultraviolet B | - |
dc.subject.keywordAuthor | Human keratinocytes | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordPlus | UVB-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | HUMAN DERMAL FIBROBLAST | - |
dc.subject.keywordPlus | INDUCED DNA-DAMAGE | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | SKIN KERATINOCYTES | - |
dc.subject.keywordPlus | OXIDATIVE DAMAGE | - |
dc.subject.keywordPlus | HACAT CELLS | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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